increased startle reflex

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Response amplitude - SMRC HarwellNotch1tm1b(EUCOMM)HmguheterozygoteEarly adultH-NOTCH1-B12-TM1B2.75x10-123.44x10-13.44x10-1

Notch1 data charts

Response amplitude - S
Combination tested with the lowest p-value of 2.75x10-12
Experiments performed

A Acoustic Startle and Pre-pulse Inhibition (PPI) phenotypic assay was performed on 2583 mice. The charts show the results of measuring Response amplitude - S in 8 female, 8 male mutants compared to 1299 female, 1268 male controls. The mutants are for the Notch1tm1b(EUCOMM)Hmgu allele.

Associated phenotype
Zygosity
heterozygote
Testing protocol
Measured value
Response amplitude - S
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
MRC Harwell

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Response amplitude - S / Box plot
Response amplitude - S / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 3.44x10-1
Genotype parameter estimate 13.093
Genotype standard error estimate 96.828
Genotype Effect P Value 3.44x10-1
Sex Parameter Estimate 13.093
Sex Standard Error Estimate 39.130
Sex Effect P Value 3.44x10-1
Intercept Estimate 72.576
Intercept Estimate Standard Error 140.938
Sex Male KO P Value 3.44x10-1
Sex Female KO P Value 3.44x10-1
WT Residuals Normality Tests 1.59x10-18
KO Residuals Normality Tests 5.84x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 8.324
Bandwidth (l)201

Experimental data download

Download data as:  

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