A Acoustic Startle and Pre-pulse Inhibition (PPI) phenotypic assay was performed on 2583 mice. The charts show the results of measuring Response amplitude - S in 8 female, 8 male mutants compared to 1299 female, 1268 male controls. The mutants are for the Notch1tm1b(EUCOMM)Hmgu allele.
increased startle reflex
Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Response amplitude - S | MRC Harwell | Notch1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | H-NOTCH1-B12-TM1B | 2.75x10-12 | 3.44x10-1 | 3.44x10-1 |
Notch1 data charts
Response amplitude - SExperiments performed
Associated phenotype
Zygosity
heterozygote
Testing protocol
Measured value
Response amplitude - S
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
MRC Harwell
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
Response amplitude - S / Box plot
Response amplitude - S / Scatter plot
Results of statistical analysis
Genotype P value
3.44x10-1
Genotype*Female P value
3.44x10-1
Genotype*Male P value
2.75x10-12
Classification
Overally insignificant [level = 1e-04 , pvalue = 0.344297145988484 ]; but with phenotype threshold value 1e-04 - males only
Summary statistics of all data in the dataset
Statistical method
Batch effect significant | true |
Variance significant | true |
Genotype*Sex interaction effect p value | 3.44x10-1 |
Genotype parameter estimate | 13.093 |
Genotype standard error estimate | 96.828 |
Genotype Effect P Value | 3.44x10-1 |
Sex Parameter Estimate | 13.093 |
Sex Standard Error Estimate | 39.130 |
Sex Effect P Value | 3.44x10-1 |
Intercept Estimate | 72.576 |
Intercept Estimate Standard Error | 140.938 |
Sex Male KO P Value | 3.44x10-1 |
Sex Female KO P Value | 3.44x10-1 |
WT Residuals Normality Tests | 1.59x10-18 |
KO Residuals Normality Tests | 5.84x10-1 |
Statistical analysis API access
Experimental data download
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