increased leukocyte cell number

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P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



White blood cell count	JAX	Ankrd52^em1(IMPC)J	heterozygote		Early adult	JR32229				2.74x10^-3	6.01x10^-6	2.49x10^-6

Ankrd52 data charts

White blood cell count

Combination tested with the lowest p-value of 2.49x10^-6

Experiments performed

A Hematology phenotypic assay was performed on 1022 mice. The charts show the results of measuring White blood cell count in 6 female, 4 male mutants compared to 512 female, 500 male controls. The mutants are for the Ankrd52^em1(IMPC)J allele.

Associated phenotype

increased leukocyte cell number

Zygosity

heterozygote

Testing protocol

Hematology

Measured value

White blood cell count

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6NJ

Phenotyping center

JAX

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

White blood cell count / Box plot

White blood cell count / Scatter plot

Results of statistical analysis

Genotype P value

2.49x10^-6

Genotype*Female P value

6.01x10^-6

Genotype*Male P value

2.74x10^-3

Classification

With phenotype threshold value 1e-04 - both sexes equally

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	2.49x10^-6
Genotype parameter estimate	2.047
Genotype standard error estimate	0.790
Genotype Effect P Value	2.49x10^-6
Sex Parameter Estimate	2.047
Sex Standard Error Estimate	0.481
Sex Effect P Value	2.49x10^-6
Intercept Estimate	2.010
Intercept Estimate Standard Error	1.253
Sex Male KO P Value	2.49x10^-6
Sex Female KO P Value	2.49x10^-6
WT Residuals Normality Tests	1.07x10^-1
KO Residuals Normality Tests	4.96x10^-1