A Clinical Chemistry phenotypic assay was performed on 2539 mice. The charts show the results of measuring Alanine aminotransferase in 8 female, 8 male mutants compared to 1256 female, 1267 male controls. The mutants are for the Dhrs7bem1(IMPC)Mbp allele.
increased circulating alanine transaminase level
Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alanine aminotransferase | UC Davis | Dhrs7bem1(IMPC)Mbp | heterozygote | Early adult | CR11357 | 2.75x10-9 | 3.7x10-4 | 3.7x10-4 |
Dhrs7b data charts
Alanine aminotransferaseExperiments performed
Associated phenotype
Zygosity
heterozygote
Testing protocol
Measured value
Alanine aminotransferase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NCrl
Phenotyping center
UC Davis
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
Alanine aminotransferase / Box plot
Alanine aminotransferase / Scatter plot
Results of statistical analysis
Genotype P value
3.7x10-4
Genotype*Female P value
3.7x10-4
Genotype*Male P value
2.75x10-9
Classification
Overally insignificant [level = 1e-04 , pvalue = 0.000369716054528291 ]; but with phenotype threshold value 1e-04 - different size as males greater
Summary statistics of all data in the dataset
Statistical method
Batch effect significant | true |
Variance significant | true |
Genotype*Sex interaction effect p value | 3.7x10-4 |
Genotype parameter estimate | 0.611 |
Genotype standard error estimate | 10.921 |
Genotype Effect P Value | 3.7x10-4 |
Sex Parameter Estimate | 0.611 |
Sex Standard Error Estimate | 2.171 |
Sex Effect P Value | 3.7x10-4 |
Intercept Estimate | 28.425 |
Intercept Estimate Standard Error | 5.962 |
Sex Male KO P Value | 3.7x10-4 |
Sex Female KO P Value | 3.7x10-4 |
WT Residuals Normality Tests | 3.15x10-48 |
KO Residuals Normality Tests | 8.66x10-3 |
Statistical analysis API access
Experimental data download
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