increased red blood cell distribution width

Loading data

P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Red blood cell distribution width	WTSI	Usp22^{tm1a(KOMP)Wtsi}	heterozygote		Early adult	MDUW				1.66x10^-5	3.56x10^-1	3.56x10^-1

Usp22 data charts

Red blood cell distribution width

Combination tested with the lowest p-value of 1.66x10^-5

Experiments performed

A Hematology phenotypic assay was performed on 3054 mice. The charts show the results of measuring Red blood cell distribution width in 7 female, 7 male mutants compared to 1524 female, 1516 male controls. The mutants are for the Usp22^{tm1a(KOMP)Wtsi} allele.

Associated phenotype

increased red blood cell distribution width

Zygosity

heterozygote

Testing protocol

Hematology

Measured value

Red blood cell distribution width

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6N

Phenotyping center

WTSI

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Red blood cell distribution width / Box plot

Red blood cell distribution width / Scatter plot

Results of statistical analysis

Genotype P value

3.56x10^-1

Genotype*Female P value

3.56x10^-1

Genotype*Male P value

1.66x10^-5

Classification

Overally insignificant [level = 1e-04 , pvalue = 0.35608018606939 ]; but with phenotype threshold value 1e-04 - males only

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	3.56x10^-1
Genotype parameter estimate	0.389
Genotype standard error estimate	0.163
Genotype Effect P Value	3.56x10^-1
Sex Parameter Estimate	0.389
Sex Standard Error Estimate	0.025
Sex Effect P Value	3.56x10^-1
Intercept Estimate	13.444
Intercept Estimate Standard Error	0.081
Sex Male KO P Value	3.56x10^-1
Sex Female KO P Value	3.56x10^-1
WT Residuals Normality Tests	1.92x10^-35
KO Residuals Normality Tests	6.04x10^-2