increased mean corpuscular hemoglobin concentration

Loading data

P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Mean cell hemoglobin concentration	WTSI	Usp22^{tm1a(KOMP)Wtsi}	heterozygote		Early adult	MDUW				6.99x10^-1	6.99x10^-11	7.17x10^-11

Usp22 data charts

Mean cell hemoglobin concentration

Combination tested with the lowest p-value of 6.99x10^-11

Experiments performed

A Hematology phenotypic assay was performed on 3054 mice. The charts show the results of measuring Mean cell hemoglobin concentration in 7 female, 7 male mutants compared to 1524 female, 1516 male controls. The mutants are for the Usp22^{tm1a(KOMP)Wtsi} allele.

Associated phenotype

increased mean corpuscular hemoglobin concentration

Zygosity

heterozygote

Testing protocol

Hematology

Measured value

Mean cell hemoglobin concentration

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6N

Phenotyping center

WTSI

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Mean cell hemoglobin concentration / Box plot

Mean cell hemoglobin concentration / Scatter plot

Results of statistical analysis

Genotype P value

7.17x10^-11

Genotype*Female P value

6.99x10^-11

Genotype*Male P value

6.99x10^-1

Classification

Overally significant [level = 1e-04 , pvalue = 7.17113035619832e-11 ]; and with phenotype threshold value 1e-04 - females only

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	7.17x10^-11
Genotype parameter estimate	-0.152
Genotype standard error estimate	0.305
Genotype Effect P Value	7.17x10^-11
Sex Parameter Estimate	-0.152
Sex Standard Error Estimate	0.044
Sex Effect P Value	7.17x10^-11
Intercept Estimate	28.336
Intercept Estimate Standard Error	0.083
Sex Male KO P Value	7.17x10^-11
Sex Female KO P Value	7.17x10^-11
WT Residuals Normality Tests	8x10^-36
KO Residuals Normality Tests	3.69x10^-5