decreased grip strength

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Forelimb and hindlimb grip strength measurement meanJAXSec61a2em1(IMPC)JhomozygoteEarly adultJR335922.65x10-48.88x10-34.38x10-5

Sec61a2 data charts

Forelimb and hindlimb grip strength measurement mean
Combination tested with the lowest p-value of 4.38x10-5
Experiments performed

A Grip Strength phenotypic assay was performed on 5046 mice. The charts show the results of measuring Forelimb and hindlimb grip strength measurement mean in 8 female, 8 male mutants compared to 2530 female, 2500 male controls. The mutants are for the Sec61a2em1(IMPC)J allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Forelimb and hindlimb grip strength measurement mean
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NJ
Phenotyping center
JAX

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Forelimb and hindlimb grip strength measurement mean / Box plot
Forelimb and hindlimb grip strength measurement mean / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 4.38x10-5
Genotype parameter estimate -4.259
Genotype standard error estimate 4.700
Genotype Effect P Value 4.38x10-5
Sex Parameter Estimate -4.259
Sex Standard Error Estimate 2.161
Sex Effect P Value 4.38x10-5
Intercept Estimate 117.459
Intercept Estimate Standard Error 7.432
Sex Male KO P Value 4.38x10-5
Sex Female KO P Value 4.38x10-5
WT Residuals Normality Tests 6.01x10-2
KO Residuals Normality Tests 5.08x10-2

Windowing parameters

View documentation about soft windowing
Sharpness (k) 1.177
Bandwidth (l)272

Experimental data download

Download data as:  

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