increased circulating alanine transaminase level

Loading data

P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Alanine aminotransferase	MRC Harwell	Usp54^{tm1b(KOMP)Wtsi}	homozygote		Early adult	H-USP54-B10-TM1B				4.54x10^-7	3.03x10^-1	3.03x10^-1

Usp54 data charts

Alanine aminotransferase

Combination tested with the lowest p-value of 4.54x10^-7

Experiments performed

A Clinical Chemistry phenotypic assay was performed on 4429 mice. The charts show the results of measuring Alanine aminotransferase in 8 female, 8 male mutants compared to 2216 female, 2197 male controls. The mutants are for the Usp54^{tm1b(KOMP)Wtsi} allele.

Associated phenotype

increased circulating alanine transaminase level

Zygosity

homozygote

Testing protocol

Clinical Chemistry

Measured value

Alanine aminotransferase

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6NTac

Phenotyping center

MRC Harwell

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Alanine aminotransferase / Box plot

Alanine aminotransferase / Scatter plot

Results of statistical analysis

Genotype P value

3.03x10^-1

Genotype*Female P value

3.03x10^-1

Genotype*Male P value

4.54x10^-7

Classification

Overally insignificant [level = 1e-04 , pvalue = 0.302701493735262 ]; but with phenotype threshold value 1e-04 - males only

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	3.03x10^-1
Genotype parameter estimate	2.278
Genotype standard error estimate	2.970
Genotype Effect P Value	3.03x10^-1
Sex Parameter Estimate	2.278
Sex Standard Error Estimate	0.580
Sex Effect P Value	3.03x10^-1
Intercept Estimate	26.086
Intercept Estimate Standard Error	1.941
Sex Male KO P Value	3.03x10^-1
Sex Female KO P Value	3.03x10^-1
WT Residuals Normality Tests	1.86x10^-55
KO Residuals Normality Tests	2.65x10^-1