increased circulating alanine transaminase level

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alanine aminotransferaseHMGUAoc1tm1b(EUCOMM)HmguhomozygoteEarly adultH4340-HEPD0615_1_A11-11.36x10-59.85x10-19.32x10-1

Aoc1 data charts

Alanine aminotransferase
Combination tested with the lowest p-value of 1.36x10-5
Experiments performed

A Clinical Chemistry phenotypic assay was performed on 1874 mice. The charts show the results of measuring Alanine aminotransferase in 6 female, 6 male mutants compared to 914 female, 948 male controls. The mutants are for the Aoc1tm1b(EUCOMM)Hmgu allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Alanine aminotransferase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
HMGU

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Alanine aminotransferase / Box plot
Alanine aminotransferase / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 9.32x10-1
Genotype parameter estimate 6.101
Genotype standard error estimate 8.443
Genotype Effect P Value 9.32x10-1
Sex Parameter Estimate 6.101
Sex Standard Error Estimate 1.460
Sex Effect P Value 9.32x10-1
Intercept Estimate 30.779
Intercept Estimate Standard Error 1.361
Sex Male KO P Value 9.32x10-1
Sex Female KO P Value 9.32x10-1
WT Residuals Normality Tests 2.22x10-38
KO Residuals Normality Tests 1.17x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 8.324
Bandwidth (l)173

Experimental data download

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