A Clinical Chemistry phenotypic assay was performed on 1874 mice. The charts show the results of measuring Alanine aminotransferase in 6 female, 6 male mutants compared to 914 female, 948 male controls. The mutants are for the Aoc1tm1b(EUCOMM)Hmgu allele.
increased circulating alanine transaminase level
Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alanine aminotransferase | HMGU | Aoc1tm1b(EUCOMM)Hmgu | homozygote | Early adult | H4340-HEPD0615_1_A11-1 | 1.36x10-5 | 9.85x10-1 | 9.32x10-1 |
Aoc1 data charts
Alanine aminotransferaseExperiments performed
Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Alanine aminotransferase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
HMGU
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
Alanine aminotransferase / Box plot
Alanine aminotransferase / Scatter plot
Results of statistical analysis
Genotype P value
9.32x10-1
Genotype*Female P value
9.85x10-1
Genotype*Male P value
1.36x10-5
Classification
Overally insignificant [level = 1e-04 , pvalue = 0.932130083378999 ]; but with phenotype threshold value 1e-04 - males only
Summary statistics of all data in the dataset
Statistical method
Batch effect significant | true |
Variance significant | true |
Genotype*Sex interaction effect p value | 9.32x10-1 |
Genotype parameter estimate | 6.101 |
Genotype standard error estimate | 8.443 |
Genotype Effect P Value | 9.32x10-1 |
Sex Parameter Estimate | 6.101 |
Sex Standard Error Estimate | 1.460 |
Sex Effect P Value | 9.32x10-1 |
Intercept Estimate | 30.779 |
Intercept Estimate Standard Error | 1.361 |
Sex Male KO P Value | 9.32x10-1 |
Sex Female KO P Value | 9.32x10-1 |
WT Residuals Normality Tests | 2.22x10-38 |
KO Residuals Normality Tests | 1.17x10-1 |
Statistical analysis API access
Experimental data download
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