Intraperitoneal glucose tolerance test

Loading data

P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Area under glucose response curve	HMGU	Knl1^{tm1b(EUCOMM)Hmgu}	heterozygote		Early adult	HMGU-HEPD0665_2_E05-1-1				9.49x10^-6	7.03x10^-1	7.03x10^-1

Knl1 data charts

Area under glucose response curve

Combination tested with the lowest p-value of 9.49x10^-6

Experiments performed

A Intraperitoneal glucose tolerance test (IPGTT) phenotypic assay was performed on 1402 mice. The charts show the results of measuring Area under glucose response curve in 10 female, 10 male mutants compared to 672 female, 710 male controls. The mutants are for the Knl1^{tm1b(EUCOMM)Hmgu} allele.

Associated phenotype

impaired glucose tolerance

Zygosity

heterozygote

Testing protocol

Intraperitoneal glucose tolerance test (IPGTT)

Measured value

Area under glucose response curve

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6NTac

Phenotyping center

HMGU

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Area under glucose response curve / Box plot

Area under glucose response curve / Scatter plot

Results of statistical analysis

Genotype P value

7.03x10^-1

Genotype*Female P value

7.03x10^-1

Genotype*Male P value

9.49x10^-6

Classification

Overally insignificant [level = 1e-04 , pvalue = 0.702502961192478 ]; but with phenotype threshold value 1e-04 - males only

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	7.03x10^-1
Genotype parameter estimate	4958.368
Genotype standard error estimate	918.843
Genotype Effect P Value	7.03x10^-1
Sex Parameter Estimate	4958.368
Sex Standard Error Estimate	367.648
Sex Effect P Value	7.03x10^-1
Intercept Estimate	11226.419
Intercept Estimate Standard Error	338.749
Sex Male KO P Value	7.03x10^-1
Sex Female KO P Value	7.03x10^-1
WT Residuals Normality Tests	1.75x10^-3
KO Residuals Normality Tests	2.81x10^-2