increased circulating alanine transaminase level

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alanine aminotransferaseUC DavisMei4em1(IMPC)MbphomozygoteEarly adultCR108254.63x10-11.38x10-71.38x10-7

Mei4 data charts

Alanine aminotransferase
Combination tested with the lowest p-value of 1.38x10-7
Experiments performed

A Clinical Chemistry phenotypic assay was performed on 2537 mice. The charts show the results of measuring Alanine aminotransferase in 7 female, 7 male mutants compared to 1256 female, 1267 male controls. The mutants are for the Mei4em1(IMPC)Mbp allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Alanine aminotransferase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NCrl
Phenotyping center
UC Davis

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Alanine aminotransferase / Box plot
Alanine aminotransferase / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 1.38x10-7
Genotype parameter estimate 0.518
Genotype standard error estimate 11.018
Genotype Effect P Value 1.38x10-7
Sex Parameter Estimate 0.518
Sex Standard Error Estimate 2.118
Sex Effect P Value 1.38x10-7
Intercept Estimate 26.629
Intercept Estimate Standard Error 5.792
Sex Male KO P Value 1.38x10-7
Sex Female KO P Value 1.38x10-7
WT Residuals Normality Tests 2.75x10-46
KO Residuals Normality Tests 7.95x10-4

Windowing parameters

View documentation about soft windowing
Sharpness (k) 2.040
Bandwidth (l)775

Experimental data download

Download data as:  

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