A Clinical Chemistry phenotypic assay was performed on 2537 mice. The charts show the results of measuring Alanine aminotransferase in 7 female, 7 male mutants compared to 1256 female, 1267 male controls. The mutants are for the Mei4em1(IMPC)Mbp allele.
increased circulating alanine transaminase level
Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alanine aminotransferase | UC Davis | Mei4em1(IMPC)Mbp | homozygote | Early adult | CR10825 | 4.63x10-1 | 1.38x10-7 | 1.38x10-7 |
Mei4 data charts
Alanine aminotransferaseExperiments performed
Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Alanine aminotransferase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NCrl
Phenotyping center
UC Davis
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
Alanine aminotransferase / Box plot
Alanine aminotransferase / Scatter plot
Results of statistical analysis
Genotype P value
1.38x10-7
Genotype*Female P value
1.38x10-7
Genotype*Male P value
4.63x10-1
Classification
Overally significant [level = 1e-04 , pvalue = 1.37568461844317e-07 ]; and with phenotype threshold value 1e-04 - females only
Summary statistics of all data in the dataset
Statistical method
Batch effect significant | true |
Variance significant | true |
Genotype*Sex interaction effect p value | 1.38x10-7 |
Genotype parameter estimate | 0.518 |
Genotype standard error estimate | 11.018 |
Genotype Effect P Value | 1.38x10-7 |
Sex Parameter Estimate | 0.518 |
Sex Standard Error Estimate | 2.118 |
Sex Effect P Value | 1.38x10-7 |
Intercept Estimate | 26.629 |
Intercept Estimate Standard Error | 5.792 |
Sex Male KO P Value | 1.38x10-7 |
Sex Female KO P Value | 1.38x10-7 |
WT Residuals Normality Tests | 2.75x10-46 |
KO Residuals Normality Tests | 7.95x10-4 |
Statistical analysis API access
Experimental data download
Download data as: