decreased grip strength

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Forelimb and hindlimb grip strength normalised against body weightJAXTtc7em1(IMPC)JheterozygoteEarly adultJR319933.15x10-42.94x10-82.94x10-8
Forelimb and hindlimb grip strength measurement meanJAXTtc7em1(IMPC)JheterozygoteEarly adultJR319932.27x10-41.53x10-54.42x10-6

Ttc7 data charts

Forelimb and hindlimb grip strength normalised against body weight
Combination tested with the lowest p-value of 2.94x10-8
Experiments performed

A Grip Strength phenotypic assay was performed on 5047 mice. The charts show the results of measuring Forelimb and hindlimb grip strength normalised against body weight in 8 female, 8 male mutants compared to 2530 female, 2501 male controls. The mutants are for the Ttc7em1(IMPC)J allele.

Associated phenotype
Zygosity
heterozygote
Testing protocol
Measured value
Forelimb and hindlimb grip strength normalised against body weight
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NJ
Phenotyping center
JAX

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Forelimb and hindlimb grip strength normalised against body weight / Box plot
Forelimb and hindlimb grip strength normalised against body weight / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 2.94x10-8
Genotype parameter estimate -2.033
Genotype standard error estimate 0.364
Genotype Effect P Value 2.94x10-8
Sex Parameter Estimate -2.033
Sex Standard Error Estimate 0.113
Sex Effect P Value 2.94x10-8
Intercept Estimate 10.711
Intercept Estimate Standard Error 0.254
Sex Male KO P Value 2.94x10-8
Sex Female KO P Value 2.94x10-8
WT Residuals Normality Tests 6.02x10-2
KO Residuals Normality Tests 1.65x10-2

Windowing parameters

View documentation about soft windowing
Sharpness (k) 0.532
Bandwidth (l)52

Experimental data download

Download data as:  

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