abnormal lens morphology

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Mean left eye lens densityHMGUCotl1tm1b(EUCOMM)HmguhomozygoteEarly adultH4640-HEPD0672_2_B07-11.26x10-73.5x10-72.01x10-11
Max left eye lens densityHMGUCotl1tm1b(EUCOMM)HmguhomozygoteEarly adultH4640-HEPD0672_2_B07-12.54x10-41.5x10-49.35x10-7
Min left eye lens densityHMGUCotl1tm1b(EUCOMM)HmguhomozygoteEarly adultH4640-HEPD0672_2_B07-16.59x10-42.14x10-45x10-6
Mean right eye lens densityHMGUCotl1tm1b(EUCOMM)HmguhomozygoteEarly adultH4640-HEPD0672_2_B07-16.32x10-52.39x10-36.49x10-6

Cotl1 data charts

Mean left eye lens density
Combination tested with the lowest p-value of 2.01x10-11
Experiments performed

A Eye Morphology phenotypic assay was performed on 1962 mice. The charts show the results of measuring Mean left eye lens density in 8 female, 7 male mutants compared to 957 female, 990 male controls. The mutants are for the Cotl1tm1b(EUCOMM)Hmgu allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Mean left eye lens density
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
HMGU

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Mean left eye lens density / Box plot
Mean left eye lens density / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 2.01x10-11
Genotype parameter estimate N/A
Genotype standard error estimate 0.235
Genotype Effect P Value 2.01x10-11
Sex Parameter Estimate N/A
Sex Standard Error Estimate N/A
Sex Effect P Value 2.01x10-11
Intercept Estimate 5.921
Intercept Estimate Standard Error 0.381
Sex Male KO P Value 2.01x10-11
Sex Female KO P Value 2.01x10-11
WT Residuals Normality Tests 1.13x10-7
KO Residuals Normality Tests 8.45x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 0.565
Bandwidth (l)69

Experimental data download

Download data as:  

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