A Clinical Chemistry phenotypic assay was performed on 4430 mice. The charts show the results of measuring Alkaline phosphatase in 8 female, 8 male mutants compared to 2216 female, 2198 male controls. The mutants are for the Leprotl1tm1b(EUCOMM)Hmgu allele.
increased circulating alkaline phosphatase level
Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alkaline phosphatase | MRC Harwell | Leprotl1tm1b(EUCOMM)Hmgu | homozygote | Early adult | H-LEPROTL1-H12-TM1B | 7.49x10-4 | 4.35x10-9 | 3.6x10-11 |
Leprotl1 data charts
Alkaline phosphataseExperiments performed
Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Alkaline phosphatase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
MRC Harwell
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
Alkaline phosphatase / Box plot
Alkaline phosphatase / Scatter plot
Results of statistical analysis
Genotype P value
3.6x10-11
Genotype*Female P value
4.35x10-9
Genotype*Male P value
7.49x10-4
Classification
With phenotype threshold value 1e-04 - both sexes equally
Summary statistics of all data in the dataset
Statistical method
Batch effect significant | true |
Variance significant | true |
Genotype*Sex interaction effect p value | 3.6x10-11 |
Genotype parameter estimate | -30.238 |
Genotype standard error estimate | 2.951 |
Genotype Effect P Value | 3.6x10-11 |
Sex Parameter Estimate | -30.238 |
Sex Standard Error Estimate | 1.721 |
Sex Effect P Value | 3.6x10-11 |
Intercept Estimate | 162.327 |
Intercept Estimate Standard Error | 5.748 |
Sex Male KO P Value | 3.6x10-11 |
Sex Female KO P Value | 3.6x10-11 |
WT Residuals Normality Tests | 5.21x10-2 |
KO Residuals Normality Tests | 8.19x10-1 |
Statistical analysis API access
Experimental data download
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