increased circulating alkaline phosphatase level

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alkaline phosphataseMRC HarwellLeprotl1tm1b(EUCOMM)HmguhomozygoteEarly adultH-LEPROTL1-H12-TM1B7.49x10-44.35x10-93.6x10-11

Leprotl1 data charts

Alkaline phosphatase
Combination tested with the lowest p-value of 3.6x10-11
Experiments performed

A Clinical Chemistry phenotypic assay was performed on 4430 mice. The charts show the results of measuring Alkaline phosphatase in 8 female, 8 male mutants compared to 2216 female, 2198 male controls. The mutants are for the Leprotl1tm1b(EUCOMM)Hmgu allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Alkaline phosphatase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NTac
Phenotyping center
MRC Harwell

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Alkaline phosphatase / Box plot
Alkaline phosphatase / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 3.6x10-11
Genotype parameter estimate -30.238
Genotype standard error estimate 2.951
Genotype Effect P Value 3.6x10-11
Sex Parameter Estimate -30.238
Sex Standard Error Estimate 1.721
Sex Effect P Value 3.6x10-11
Intercept Estimate 162.327
Intercept Estimate Standard Error 5.748
Sex Male KO P Value 3.6x10-11
Sex Female KO P Value 3.6x10-11
WT Residuals Normality Tests 5.21x10-2
KO Residuals Normality Tests 8.19x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 5.426
Bandwidth (l)137

Experimental data download

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