decreased anxiety-related response

Loading data

P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Percentage center movement time	MRC Harwell	Leprotl1^{tm1b(EUCOMM)Hmgu}	homozygote		Early adult	H-LEPROTL1-H12-TM1B				3.68x10^-5	9.21x10^-4	2.27x10^-7

Leprotl1 data charts

Percentage center movement time

Combination tested with the lowest p-value of 2.27x10^-7

Experiments performed

A Open Field phenotypic assay was performed on 4786 mice. The charts show the results of measuring Percentage center movement time in 8 female, 8 male mutants compared to 2388 female, 2382 male controls. The mutants are for the Leprotl1^{tm1b(EUCOMM)Hmgu} allele.

Associated phenotype

decreased anxiety-related response

Zygosity

homozygote

Testing protocol

Open Field

Measured value

Percentage center movement time

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6NTac

Phenotyping center

MRC Harwell

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Percentage center movement time / Box plot

Percentage center movement time / Scatter plot

Results of statistical analysis

Genotype P value

2.27x10^-7

Genotype*Female P value

9.21x10^-4

Genotype*Male P value

3.68x10^-5

Classification

With phenotype threshold value 1e-04 - both sexes equally

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	2.27x10^-7
Genotype parameter estimate	1.355
Genotype standard error estimate	1.042
Genotype Effect P Value	2.27x10^-7
Sex Parameter Estimate	1.355
Sex Standard Error Estimate	0.144
Sex Effect P Value	2.27x10^-7
Intercept Estimate	7.526
Intercept Estimate Standard Error	0.117
Sex Male KO P Value	2.27x10^-7
Sex Female KO P Value	2.27x10^-7
WT Residuals Normality Tests	2.99x10^-35
KO Residuals Normality Tests	1.55x10^-1