increased lymphocyte cell number

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P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Lymphocyte differential count	MRC Harwell	Synj1^{tm1b(EUCOMM)Wtsi}	heterozygote		Early adult	H-SYNJ1-C03-TM1B				1.88x10^-13	8.1x10^-1	8.06x10^-1

Synj1 data charts

Lymphocyte differential count

Combination tested with the lowest p-value of 1.88x10^-13

Experiments performed

A Hematology phenotypic assay was performed on 780 mice. The charts show the results of measuring Lymphocyte differential count in 8 female, 8 male mutants compared to 382 female, 382 male controls. The mutants are for the Synj1^{tm1b(EUCOMM)Wtsi} allele.

Associated phenotype

increased lymphocyte cell number

Zygosity

heterozygote

Testing protocol

Hematology

Measured value

Lymphocyte differential count

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6NTac

Phenotyping center

MRC Harwell

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Lymphocyte differential count / Box plot

Lymphocyte differential count / Scatter plot

Results of statistical analysis

Genotype P value

8.06x10^-1

Genotype*Female P value

8.1x10^-1

Genotype*Male P value

1.88x10^-13

Classification

Overally insignificant [level = 1e-04 , pvalue = 0.805559327545168 ]; but with phenotype threshold value 1e-04 - males only

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	8.06x10^-1
Genotype parameter estimate	-1.087
Genotype standard error estimate	2.266
Genotype Effect P Value	8.06x10^-1
Sex Parameter Estimate	-1.087
Sex Standard Error Estimate	0.624
Sex Effect P Value	8.06x10^-1
Intercept Estimate	83.655
Intercept Estimate Standard Error	0.664
Sex Male KO P Value	8.06x10^-1
Sex Female KO P Value	8.06x10^-1
WT Residuals Normality Tests	8.03x10^-21
KO Residuals Normality Tests	7.81x10^-1