A Clinical Chemistry phenotypic assay was performed on 2957 mice. The charts show the results of measuring Alanine aminotransferase in 7 female, 8 male mutants compared to 1488 female, 1454 male controls. The mutants are for the Hsf4tm1b(KOMP)Wtsi allele.
increased circulating alanine transaminase level
Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Alanine aminotransferase | JAX | Hsf4tm1b(KOMP)Wtsi | homozygote | Early adult | JR21902 | 1.23x10-5 | 1.93x10-1 | 1.93x10-1 |
Hsf4 data charts
Alanine aminotransferaseExperiments performed
Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Alanine aminotransferase
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NJ
Phenotyping center
JAX
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
Alanine aminotransferase / Box plot
Alanine aminotransferase / Scatter plot
Results of statistical analysis
Genotype P value
1.93x10-1
Genotype*Female P value
1.93x10-1
Genotype*Male P value
1.23x10-5
Classification
Overally insignificant [level = 1e-04 , pvalue = 0.19261022802482 ]; but with phenotype threshold value 1e-04 - males only
Summary statistics of all data in the dataset
Statistical method
Batch effect significant | true |
Variance significant | true |
Genotype*Sex interaction effect p value | 1.93x10-1 |
Genotype parameter estimate | 8.691 |
Genotype standard error estimate | 17.128 |
Genotype Effect P Value | 1.93x10-1 |
Sex Parameter Estimate | 8.691 |
Sex Standard Error Estimate | 4.515 |
Sex Effect P Value | 1.93x10-1 |
Intercept Estimate | 110.508 |
Intercept Estimate Standard Error | 16.152 |
Sex Male KO P Value | 1.93x10-1 |
Sex Female KO P Value | 1.93x10-1 |
WT Residuals Normality Tests | 1.02x10-39 |
KO Residuals Normality Tests | 6.28x10-2 |
Statistical analysis API access
Experimental data download
Download data as: