decreased grip strength

  Loading data
P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
Forelimb and hindlimb grip strength normalised against body weightUC DavisTle4em1(IMPC)MbphomozygoteEarly adultCR15083.62x10-43.4x10-41.33x10-6

Tle4 data charts

Forelimb and hindlimb grip strength normalised against body weight
Combination tested with the lowest p-value of 1.33x10-6
Experiments performed

A Grip Strength phenotypic assay was performed on 2177 mice. The charts show the results of measuring Forelimb and hindlimb grip strength normalised against body weight in 7 female, 7 male mutants compared to 1088 female, 1075 male controls. The mutants are for the Tle4em1(IMPC)Mbp allele.

Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Forelimb and hindlimb grip strength normalised against body weight
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6NCrl
Phenotyping center
UC Davis

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Forelimb and hindlimb grip strength normalised against body weight / Box plot
Forelimb and hindlimb grip strength normalised against body weight / Scatter plot

Results of statistical analysis

Summary statistics of all data in the dataset

Statistical method

Batch effect significant true
Variance significant true
Genotype*Sex interaction effect p value 1.33x10-6
Genotype parameter estimate -1.293
Genotype standard error estimate 0.315
Genotype Effect P Value 1.33x10-6
Sex Parameter Estimate -1.293
Sex Standard Error Estimate 0.053
Sex Effect P Value 1.33x10-6
Intercept Estimate 11.432
Intercept Estimate Standard Error 0.055
Sex Male KO P Value 1.33x10-6
Sex Female KO P Value 1.33x10-6
WT Residuals Normality Tests 1.04x10-4
KO Residuals Normality Tests 8.96x10-1

Windowing parameters

View documentation about soft windowing
Sharpness (k) 5.426
Bandwidth (l)402

Experimental data download

Download data as:  

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