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Phenotype: increased effector memory T-helper cell number

Definition
increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased effector memory T-helper cell number

Total number of significant genotype-phenotype associations: 20

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD4+ T helper cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD4+ T helper cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD4+ T helper cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD4+ T helper cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gda
Gdatm1a(KOMP)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Resting CD4+ T helper cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Nipsnap3a
Nipsnap3atm1b(KOMP)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased effector memory T-helper cell number Resting CD4+ T helper cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Ydjc
Ydjctm1(KOMP)Wtsi 		HOM   Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
3425401B19Rik
3425401B19Rikem2(IMPC)Ccpcz 		HOM Early adult increased effector memory T-helper cell number CD4 CD44-CD62L+ T cells
Immunophenotyping		 CCP-IMG
IMPC		 2.81×10-08
Prdm14
Prdm14tm1a(EUCOMM)Wtsi 		HOM Early adult increased effector memory T-helper cell number CD4 CD44-CD62L+ T cells
Immunophenotyping		 BCM
IMPC		 1.09×10-07
Cnpy2
Cnpy2em1(IMPC)Wtsi 		HET Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.11×10-07
Churc1
Churc1tm1b(EUCOMM)Wtsi 		HOM Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.05×10-06
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.42×10-06
Cpm
Cpmem1(IMPC)Ccpcz 		HOM Early adult increased effector memory T-helper cell number Resting CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.59×10-06
Psmb11
Psmb11em1(IMPC)Ccpcz 		HOM Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.28×10-05
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult increased effector memory T-helper cell number CD4 CD44+CD62L+ T cells
Immunophenotyping		 CCP-IMG
IMPC		 1.58×10-05
Rnf128
Rnf128tm1.1(KOMP)Vlcg 		HEM Early adult increased effector memory T-helper cell number Effector CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.44×10-05
Irag1
Irag1em1(IMPC)Ccpcz 		HOM Early adult increased effector memory T-helper cell number Resting CD4+ T helper cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 8.66×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping

 Phenotype associations stats

2.54% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased effector memory T-helper cell number (20/786)

1.17% females (4/343) 1.75% males (6/343)

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