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Phenotype: abnormal mature NK cell morphology

Definition
any structural anomaly of NK cells expressing the maturation marker CD11b
Synonyms
abnormal mature natural killer cell morphology,  abnormal lymphokine activated killer cell morphology
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal mature NK cell morphology

Total number of significant genotype-phenotype associations: 20

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased mature NK cell number Mature NK cells - % of NK cellls
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult decreased mature NK cell number Mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of mature NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of mature NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased mature NK cell number Mature NK cells - % of NK cellls
Spleen Immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult increased mature NK cell number Mature NK cells - % of NK cellls
Spleen Immunophenotyping		 WTSI
3i		 0.00
Rwdd1
Rwdd1tm1b(KOMP)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of mature NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Spink14
Spink14tm1e(KOMP)Wtsi 		HOM   Early adult decreased mature NK cell number Mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HET Early adult decreased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 CCP-IMG
IMPC		 5.05×10-09
Tmprss6
Tmprss6tm1b(EUCOMM)Wtsi 		HOM Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 ICS
IMPC		 2.61×10-06
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased Ly6C-positive mature NK cell number NK Subsets (Q2)
Immunophenotyping		 HMGU
IMPC		 3.12×10-06
Cluh
Cluhem1(IMPC)Ccpcz 		HET Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 CCP-IMG
IMPC		 1.14×10-05
Asb2
Asb2tm2b(KOMP)Wtsi 		HET Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 KMPC
IMPC		 2.36×10-05
Tent5a
Tent5aem1(IMPC)Ccpcz 		HOM   Early adult decreased Ly6C-positive mature NK cell number NK Subsets (Q2)
Immunophenotyping		 CCP-IMG
IMPC		 2.92×10-05
Spink6
Spink6em1(IMPC)Ccpcz 		HOM Early adult increased Ly6C-positive mature NK cell number NK Subsets (Q2)
Immunophenotyping		 CCP-IMG
IMPC		 6.34×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
FACS
Spleen Immunophenotyping

 Phenotype associations stats

3.79% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal mature NK cell morphology (16/422)

6.10% females (5/82) 3.66% males (3/82)

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