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Phenotype: increased CD11b-high dendritic cell number

Definition
increase in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased CD11b-high dendritic cell number

Total number of significant genotype-phenotype associations: 3

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Trappc9
Trappc9tm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD11b-high dendritic cell number CD11b-high cDC - % of cDC
Spleen Immunophenotyping		 WTSI
3i		 0.00
Lgr5
Lgr5em1(IMPC)Kmpc 		HET Early adult increased CD11b-high dendritic cell number cDCs CD11b Type
Immunophenotyping		 KMPC
IMPC		 7.90×10-06
Tmprss6
Tmprss6tm1b(EUCOMM)Wtsi 		HOM Early adult increased CD11b-high dendritic cell number cDCs CD11b Type
Immunophenotyping		 ICS
IMPC		 1.97×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping

 Phenotype associations stats

0.58% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased CD11b-high dendritic cell number (3/519)

0.00% females (0/75) 2.74% males (2/73)

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