Phenotype: decreased threshold for auditory brainstem response

Definition
reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased threshold for auditory brainstem response

Total number of significant genotype-phenotype associations: 29

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Rab10
Rab10em1(IMPC)J
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 3.64×10-09
Romo1
Romo1em1(IMPC)KMPC
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 24kHz-evoked ABR Threshold KMPC | IMPC 2.48×10-08
Med10
Med10em1(IMPC)J
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 7.00×10-08
Dlec1
Dlec1tm1b(EUCOMM)Wtsi
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | Click-evoked ABR threshold HMGU | IMPC 2.00×10-07
Gm12258
Gm12258tm1b(EUCOMM)Hmgu
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold ICS | IMPC 2.00×10-07
Hilpda
Hilpdaem1(IMPC)Mhzh
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 12kHz-evoked ABR Threshold MARC | IMPC 5.00×10-07
Dnajc17
Dnajc17tm1b(EUCOMM)Hmgu
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 4.20×10-06
Tssk4
Tssk4em1(IMPC)J
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 12kHz-evoked ABR Threshold JAX | IMPC 5.75×10-06
Frs2
Frs2tm1b(EUCOMM)Wtsi
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold MRC Harwell | IMPC 6.00×10-06
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | Click-evoked ABR threshold HMGU | IMPC 7.60×10-06
Zdhhc11
Zdhhc11tm1.1(KOMP)Vlcg
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold JAX | IMPC 9.30×10-06
Iqgap2
Iqgap2tm1b(KOMP)Wtsi
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 9.90×10-06
Fam53b
Fam53btm1b(EUCOMM)Hmgu
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 1.07×10-05
Macrod2
Macrod2tm1.1(KOMP)Vlcg
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 18kHz-evoked ABR Threshold JAX | IMPC 1.47×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 18kHz-evoked ABR Threshold HMGU | IMPC 1.80×10-05
Bzw1
Bzw1em1(IMPC)J
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 4.23×10-05
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 6.09×10-05
Aldh1l1
Aldh1l1tm1b(KOMP)Wtsi
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold HMGU | IMPC 6.33×10-05
Dok7
Dok7tm1.1(KOMP)Vlcg
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11×10-05
Hmx2
Hmx2tm1.1(KOMP)Vlcg
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11×10-05
Plod3
Plod3tm1.1(KOMP)Wtsi
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11×10-05
Reg2
Reg2tm1.1(KOMP)Vlcg
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold UC Davis | IMPC 7.11×10-05
Stim2
Stim2tm1.1(KOMP)Vlcg
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 30kHz-evoked ABR Threshold JAX | IMPC 8.55×10-05
Ppp6c
Ppp6ctm1b(EUCOMM)Hmgu
HET postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold ICS | IMPC 9.53×10-05
Snx29
Snx29tm1b(EUCOMM)Hmgu
HOM postnatal decreased threshold for auditory brainstem response Auditory Brain Stem Response | 6kHz-evoked ABR Threshold ICS | IMPC 9.53×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.60% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased threshold for auditory brainstem response (25/4200)

0.13% females (5/3831) 0.08% males (3/3973)

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