Phenotype: prolonged ST segment

Definition
increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged ST segment

Total number of significant genotype-phenotype associations: 18

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Iah1
Iah1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
ICS
IMPC
5.87×10-08
Laptm4a
Laptm4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
ICS
IMPC
9.57×10-08
Nfat5
Nfat5tm1b(KOMP)Wtsi
HET Early adult prolonged ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
1.37×10-06
Sowaha
Sowahaem1(IMPC)Mbp
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
3.89×10-06
Carf
Carftm1.1(KOMP)Vlcg
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
6.29×10-06
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HET Early adult prolonged ST segment ST
Electrocardiogram (ECG)
ICS
IMPC
1.62×10-05
Mybl2
Mybl2tm1.1(KOMP)Vlcg
HET Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
2.15×10-05
Entr1
Entr1em1(IMPC)Mbp
HOM   Late adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
2.59×10-05
Dennd2c
Dennd2ctm1b(KOMP)Wtsi
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
2.65×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
3.32×10-05
Mical3
Mical3em1(IMPC)J
HOM   Early adult prolonged ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
3.35×10-05
Dnase1
Dnase1tm1.1(KOMP)Vlcg
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
3.81×10-05
Slc46a1
Slc46a1tm1b(KOMP)Mbp
HET Early adult prolonged ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
6.25×10-05
Toporsl
Toporsltm1.1(KOMP)Vlcg
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
6.61×10-05
Atf4
Atf4tm1(KOMP)Mbp
HET   Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
7.68×10-05
Ptk6
Ptk6tm1b(EUCOMM)Wtsi
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
8.12×10-05
Dnm1
Dnm1tm1.1(KOMP)Vlcg
HET   Early adult prolonged ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
8.47×10-05
Sh3tc1
Sh3tc1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged ST segment ST
Electrocardiogram (ECG)
ICS
IMPC
9.11×10-05

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 The way we measure

 Phenotype associations stats

0.45% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged ST segment (18/4035)

0.08% females (3/3970) 0.28% males (11/3966)

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