Definition
greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine
Synonyms
hyperuricaemia,
hyperuricemia
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with increased blood uric acid level
Total number of significant genotype-phenotype associations: 17
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Pde6b Pde6bPde6b |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical chemistry (GMC) |
HMGU EuroPhenome |
2.61×10-09 | |
| Brd7 Brd7tm3a(EUCOMM)Wtsi |
HET | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI MGP |
2.41×10-08 | |
| Vim Vimtm2Cba |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical chemistry (GMC) |
HMGU EuroPhenome |
5.12×10-08 | |
| Insl5 Insl5Insl5 |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical chemistry (GMC) |
HMGU EuroPhenome |
8.99×10-07 | |
| Acot6 Acot6tm1a(KOMP)Wtsi |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI EuroPhenome |
1.45×10-06 | |
| Nrsn2 Nrsn2em1(IMPC)Kmpc |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
KMPC IMPC |
1.72×10-06 | |
| Tpm1 Tpm1tm1a(EUCOMM)Wtsi |
HET | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI EuroPhenome |
4.59×10-06 | |
| Sytl1 Sytl1tm1a(KOMP)Wtsi |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI EuroPhenome |
6.41×10-06 | |
| Asxl1 Asxl1tm1a(EUCOMM)Wtsi |
HET | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI MGP |
1.28×10-05 | |
| Wdr47 Wdr47tm1a(EUCOMM)Wtsi |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI EuroPhenome |
1.73×10-05 | |
| Stard13 Stard13tm1a(KOMP)Wtsi |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI MGP |
2.50×10-05 | |
| Etv6 Etv6em1(IMPC)Rbrc |
HET | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
RBRC IMPC |
2.59×10-05 | |
| Sh3kbp1 Sh3kbp1tm1Ivdi |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical chemistry (GMC) |
HMGU EuroPhenome |
2.66×10-05 | |
| Abcd1 Abcd1tm1a(EUCOMM)Wtsi |
HEM | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI EuroPhenome |
6.18×10-05 | |
| Cblif Cbliftm1a(KOMP)Wtsi |
HOM | Early adult | increased blood uric acid level | Uric acid Clinical Chemistry |
WTSI MGP |
9.06×10-05 |