MP:0008810 (increased circulating iron level) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

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Phenotype: increased circulating iron level

Definition

elevation in the concentration of iron in the blood

Synonyms

hyperferremia, hyperferraemia

Significant gene associations The way we measure Phenotype stats

of tested genes

significant genes

tested genes

IMPC Gene variants with increased circulating iron level

Total number of significant genotype-phenotype associations: 79

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Agl Agl^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	0.00
Bmp6 Bmp6^{em1(IMPC)Ccpcz}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	CCP-IMG IMPC	0.00
Pcsk2 Pcsk2^em1(IMPC)H	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	0.00
Tpo Tpo^em1(IMPC)H	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	0.00
Tfr2 Tfr2^{em1(IMPC)Rbrc}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	RBRC IMPC	5.34×10^-43
Hjv Hjv^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	JAX IMPC	2.72×10^-25
Duoxa2 Duoxa2^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	7.54×10^-18
Nptn Nptn^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	1.60×10^-14
Heph Heph^{em1(IMPC)Ccpcz}	HEM	Early adult	increased circulating iron level	Iron Clinical Chemistry	CCP-IMG IMPC	5.66×10^-14
Clpp Clpp^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	1.49×10^-12
Itsn1 Itsn1^em1(IMPC)H	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	2.49×10^-10
Bhlhe40 Bhlhe40^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	3.89×10^-10
Sst Sst^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	RBRC IMPC	6.46×10^-10
Slc7a2 Slc7a2^{tm1b(EUCOMM)Hmgu}	HOM	Late adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	1.13×10^-09
Gmds Gmds^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	2.01×10^-09
Lrp1b Lrp1b^{em1(IMPC)Hmgu}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU IMPC	2.14×10^-08
Heph Heph^{em1(IMPC)Ccpcz}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	CCP-IMG IMPC	5.35×10^-08
Otp Otp^{tm1b(EUCOMM)Wtsi}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	6.64×10^-08
Cyb561 Cyb561^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell EuroPhenome	1.07×10^-07
Slc1a1 Slc1a1^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	JAX IMPC	1.61×10^-07
Ctsa Ctsa^{tm2b(EUCOMM)Hmgu}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	2.38×10^-07
Sema3f Sema3f^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	2.51×10^-07
Ergic2 Ergic2^{em1(IMPC)Hmgu}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU IMPC	3.70×10^-07
Gria1 Gria1^em1(IMPC)H	HOM	Late adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	6.96×10^-07
Epg5 Epg5^em1(IMPC)H	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	7.30×10^-07
Acsf3 Acsf3^{em1(IMPC)Hmgu}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU IMPC	8.98×10^-07
Zfyve28 Zfyve28^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	9.91×10^-07
Lrrk1 Lrrk1^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	1.20×10^-06
Nr1d1 Nr1d1^Nr1d1	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	ICS EuroPhenome	1.25×10^-06
Krt9 Krt9^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	JAX IMPC	1.70×10^-06
Slc38a10 Slc38a10^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	2.33×10^-06
Prkcz Prkcz^{tm1a(EUCOMM)Wtsi}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI EuroPhenome	2.54×10^-06
1700123O20Rik 1700123O20Rik^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	2.70×10^-06
Hbs1l Hbs1l^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	2.80×10^-06
Bach2 Bach2^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	3.88×10^-06
Susd6 Susd6^{tm1b(KOMP)Wtsi}	HOM	Late adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	4.31×10^-06
Faah Faah^em1(IMPC)H	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	5.62×10^-06
Fnip2 Fnip2^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	6.63×10^-06
Nek9 Nek9^{tm1a(EUCOMM)Wtsi}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	6.71×10^-06
Trim56 Trim56^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	6.76×10^-06
Ldlr Ldlr^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU IMPC	7.69×10^-06
Rln3 Rln3^tm1(KOMP)Mbp	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	RBRC IMPC	8.81×10^-06
Hexb Hexb^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	8.88×10^-06
Ap2a2 Ap2a2^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	9.06×10^-06
Odf1 Odf1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	1.13×10^-05
Nfkb1 Nfkb1^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI EuroPhenome	1.38×10^-05
Dpp9 Dpp9^{tm1b(EUCOMM)Hmgu}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU IMPC	1.42×10^-05
Trpc3 Trpc3^Mwk	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell EuroPhenome	1.47×10^-05
Prmt5 Prmt5^{tm2a(EUCOMM)Wtsi}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI EuroPhenome	1.50×10^-05
Ap4m1 Ap4m1^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	1.79×10^-05
Ptprd Ptprd^{tm2a(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	1.92×10^-05
Dip2a Dip2a^{tm2b(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	2.81×10^-05
Lepr Lepr^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	2.91×10^-05
Sgsm1 Sgsm1^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	3.39×10^-05
Tppp Tppp^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	JAX IMPC	3.39×10^-05
Pde10a Pde10a^em1(IMPC)H	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	3.49×10^-05
Fancd2 Fancd2^{em1(IMPC)Hmgu}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU IMPC	3.60×10^-05
Myl4 Myl4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU EuroPhenome	3.72×10^-05
Ncf2 Ncf2^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	5.02×10^-05
Tmed3 Tmed3^{tm2b(EUCOMM)Hmgu}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	5.16×10^-05
Cckbr Cckbr^em1(IMPC)H	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	5.69×10^-05
Apoo Apoo^{tm1b(KOMP)Wtsi}	HEM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	6.56×10^-05
Bbof1 Bbof1^{em1(IMPC)Marc}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	MARC IMPC	7.05×10^-05
Mir96 Mir96^{tm3.2(IMPC)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	7.23×10^-05
Apbb1ip Apbb1ip^{em1(IMPC)Ccpcz}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	CCP-IMG IMPC	7.51×10^-05
Nr0b1 Nr0b1^{em2(IMPC)Wtsi}	HEM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	7.63×10^-05
Tspan17 Tspan17^em1(IMPC)H	HOM	Late adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	7.70×10^-05
Exoc3l2 Exoc3l2^{tm1b(KOMP)Wtsi}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	8.17×10^-05
Ccnd2 Ccnd2^{tm1b(KOMP)Mbp}	HOM	Late adult	increased circulating iron level	Iron Clinical Chemistry	MRC Harwell IMPC	8.69×10^-05
Cmpk1 Cmpk1^{tm1b(EUCOMM)Wtsi}	HET	Early adult	increased circulating iron level	Iron Clinical Chemistry	HMGU IMPC	9.30×10^-05
Prrg2 Prrg2^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	9.32×10^-05
Naaa Naaa^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI IMPC	9.42×10^-05
Crlf3 Crlf3^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating iron level	Iron Clinical Chemistry	WTSI EuroPhenome	9.48×10^-05

Download data as: TSV XLS

The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Terminal Bleed

Phenotype associations stats

1.92% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating iron level (72/3751)

1.40% females (52/3718) 0.51% males (19/3704)

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Phenotype: increased circulating iron level

IMPC Gene variants with increased circulating iron level

The way we measure

Phenotype associations stats

The IMPC Newsletter

Access Data Release 20.1 Data