Phenotype: abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

Definition
any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
Synonyms
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T-cell morphology,  abnormal CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte morphology,  abnormal CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte morphology,  abnormal CD4-positive, CD25-positive, alpha-beta Treg morphology
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

Total number of significant genotype-phenotype associations: 35

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of Treg
Spleen Immunophenotyping
WTSI
3i
0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping
WTSI
3i
0.00
Cttnbp2
Cttnbp2tm1b(KOMP)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Dph6
Dph6tm1a(KOMP)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Spleen Immunophenotyping
WTSI
3i
0.00
Dph6
Dph6tm1a(KOMP)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Spleen Immunophenotyping
WTSI
3i
0.00
Dph6
Dph6tm1a(KOMP)Wtsi
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Gmds
Gmdstm1a(KOMP)Wtsi
HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Gmds
Gmdstm1a(KOMP)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Gmds
Gmdstm1a(KOMP)Wtsi
HOM   Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping
WTSI
3i
0.00
Il27
Il27tm1b(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Pepd
Pepdtm1a(KOMP)Wtsi
HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping
WTSI
3i
0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping
WTSI
3i
0.00
Card11
Card11em1(IMPC)Ccpcz
HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
3.18×10-36
Cd38
Cd38em1(IMPC)Ccpcz
HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
4.30×10-20
Cd27
Cd27em1(IMPC)Ccpcz
HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
2.16×10-07
Mmp20
Mmp20em1(IMPC)Ccpcz
HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
2.39×10-06
Fam83h
Fam83hem1(IMPC)Ccpcz
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
2.76×10-06
Spred1
Spred1em1(IMPC)Ccpcz
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
9.48×10-06
Ltn1
Ltn1tm1b(EUCOMM)Hmgu
HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
5.89×10-05
Fgd3
Fgd3em1(IMPC)Ccpcz
HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping
CCP-IMG
IMPC
6.24×10-05

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 The way we measure

 Phenotype associations stats

0.92% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology (21/2289)

1.37% females (4/292) 1.03% males (3/291)

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