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Phenotype: abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

Definition
any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
Synonyms
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T-cell morphology,  abnormal CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte morphology,  abnormal CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte morphology,  abnormal CD4-positive, CD25-positive, alpha-beta Treg morphology
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology

Total number of significant genotype-phenotype associations: 34

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cttnbp2
Cttnbp2tm1b(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Il27
Il27tm1b(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Card11
Card11em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.18×10-36
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.30×10-20
Fam83h
Fam83hem1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.22×10-08
Cd27
Cd27em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.16×10-07
Mmp20
Mmp20em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.39×10-06
Spred1
Spred1em1(IMPC)Ccpcz 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 9.48×10-06
Ltn1
Ltn1tm1b(EUCOMM)Hmgu 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.87×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

2.51% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology (20/796)

1.20% females (4/332) 1.22% males (4/329)

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