banner
Genes Phenotypes Help, News, Blog

Phenotype: decreased NK cell number

Definition
reduction in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
Synonyms
reduced NK cell number,  reduced natural killer cell number,  decreased natural killer cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased NK cell number

Total number of significant genotype-phenotype associations: 69

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Adap1
Adap1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased immature NK cell number Immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive immature NK cell number Ly6C+ immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult decreased mature NK cell number Mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult decreased NK cell number Total NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cnot4
Cnot4tm1b(EUCOMM)Wtsi 		HET Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker NK cell number Effector NK cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive immature NK cell number Ly6C+ immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of mature NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased NK cell number Total NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
D6Wsu163e
D6Wsu163etm1b(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker NK cell number Resting NK cells - % of NK cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of mature NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM Early adult decreased NK cell number NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Fbxw26
Fbxw26tm1b(KOMP)Wtsi 		HOM   Early adult decreased memory-marker NK cell number Resting NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased mature NK cell number Mature NK cells - % of NK cellls
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased NK cell number Total NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Ifnar1
Ifnar1tm2a(EUCOMM)Wtsi 		HOM Early adult decreased KLRG1-positive NK cell number KLRG1+ mature NK cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Ncf2
Ncf2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased NK cell number NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult decreased immature NK cell number Immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Rwdd1
Rwdd1tm1b(KOMP)Wtsi 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of mature NK cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased Ly6C-positive mature NK cell number Ly6C+ mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM Early adult decreased NK cell number NK cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Spink14
Spink14tm1e(KOMP)Wtsi 		HOM   Early adult decreased immature NK cell number Immature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Spink14
Spink14tm1e(KOMP)Wtsi 		HOM   Early adult decreased mature NK cell number Mature NK cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Spink14
Spink14tm1e(KOMP)Wtsi 		HOM   Early adult decreased NK cell number Total NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM   Early adult decreased memory-marker NK cell number Effector NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM   Early adult decreased NK cell number Total NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Trappc9
Trappc9tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased KLRG1-positive NK cell number KLRG1+ NK cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Asb2
Asb2tm2b(KOMP)Wtsi 		HET Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q3)
Immunophenotyping		 KMPC
IMPC		 1.40×10-11
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased NK cell number NK cells (panel A)
Immunophenotyping		 CCP-IMG
IMPC		 7.93×10-10
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HET Early adult decreased Ly6C-positive mature NK cell number NK Subsets (Q4)
Immunophenotyping		 CCP-IMG
IMPC		 5.05×10-09
Parp1
Parp1tm1b(EUCOMM)Hmgu 		HOM   Early adult decreased NK cell number NK Cells (panel B)
Immunophenotyping		 ICS
IMPC		 1.63×10-07
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q1)
Immunophenotyping		 HMGU
IMPC		 1.13×10-06
Nr1d1
Nr1d1tm1(KOMP)Vlcg 		HOM Early adult decreased NK cell number NK cells (panel A)
Immunophenotyping		 BCM
IMPC		 1.60×10-06
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased Ly6C-positive mature NK cell number NK Subsets (Q2)
Immunophenotyping		 HMGU
IMPC		 3.12×10-06
Parvb
Parvbtm1a(EUCOMM)Wtsi 		HOM Early adult decreased NK cell number NK cell percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 4.10×10-06
Tmprss6
Tmprss6tm1b(EUCOMM)Wtsi 		HOM Early adult decreased NK cell number NK cells (panel A)
Immunophenotyping		 ICS
IMPC		 4.24×10-06
Flt3
Flt3em1(IMPC)Ccpcz 		HOM   Early adult decreased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 5.40×10-06
Agpat5
Agpat5em1(IMPC)Ccpcz 		HOM   Early adult decreased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 8.11×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM   Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q1)
Immunophenotyping		 HMGU
IMPC		 8.60×10-06
Tent5a
Tent5aem1(IMPC)Ccpcz 		HOM   Early adult decreased Ly6C-positive mature NK cell number NK Subsets (Q2)
Immunophenotyping		 CCP-IMG
IMPC		 2.92×10-05
Cd200
Cd200tm1a(KOMP)Wtsi 		HOM Early adult decreased NK cell number NK cell percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 3.09×10-05
Spink6
Spink6em1(IMPC)Ccpcz 		HOM   Early adult decreased Ly6C-positive immature NK cell number NK Subsets (Q3)
Immunophenotyping		 CCP-IMG
IMPC		 3.14×10-05
Car6
Car6em1(IMPC)Ccpcz 		HOM Early adult decreased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.09×10-05
Sla2
Sla2em1(IMPC)Ccpcz 		HOM   Early adult decreased NK cell number NK cells (Panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.11×10-05
Clk1
Clk1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased NK cell number NK cell percentage
FACs Analysis		 HMGU
EuroPhenome		 4.14×10-05
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased NK cell number NK Cells (panel B)
Immunophenotyping		 HMGU
IMPC		 8.50×10-05
Rcc1l
Rcc1ltm1a(EUCOMM)Hmgu 		HET   Early adult decreased NK cell number NK cell percentage
FACs Analysis		 HMGU
EuroPhenome		 8.93×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
FACs Analysis
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

3.50% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased NK cell number (36/1029)

1.86% females (10/538) 2.43% males (14/576)

Select a parameter    



The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter