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Phenotype: decreased circulating sodium level

Definition
less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume
Synonyms
hyponatremia,  reduced circulating sodium level,  hyponatraemia
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased circulating sodium level

Total number of significant genotype-phenotype associations: 31

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Il1r1
Il1r1em1(IMPC)Ccpcz 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 CCP-IMG
IMPC		 2.48×10-21
Dll1
Dll1tm1Gos 		HET Early adult decreased circulating sodium level Sodium
Clinical chemistry (GMC)		 HMGU
EuroPhenome		 1.00×10-12
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 CCP-IMG
IMPC		 2.78×10-10
Unc80
Unc80em1(IMPC)Tcp 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 TCP
IMPC		 6.03×10-08
Farsa
Farsatm2a(EUCOMM)Wtsi 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
IMPC		 2.30×10-07
Aldh16a1
Aldh16a1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
IMPC		 5.62×10-07
Nfkb1
Nfkb1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
EuroPhenome		 5.87×10-07
Trim9
Trim9em1(IMPC)Ccpcz 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 CCP-IMG
IMPC		 7.96×10-07
Polr2h
Polr2htm1.1(KOMP)Wtsi 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 JAX
IMPC		 2.25×10-06
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 ICS
EuroPhenome		 2.76×10-06
Art1
Art1tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 TCP
IMPC		 3.10×10-06
Ndufa8
Ndufa8tm1a(EUCOMM)Hmgu 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 HMGU
EuroPhenome		 3.99×10-06
Plet1
Plet1em1(IMPC)Wtsi 		HOM   Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
IMPC		 4.27×10-06
Asb5
Asb5em1(IMPC)Ccpcz 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 CCP-IMG
IMPC		 5.02×10-06
Cyrib
Cyribtm1b(KOMP)Wtsi 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 TCP
IMPC		 5.79×10-06
Secisbp2
Secisbp2tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
EuroPhenome		 8.50×10-06
Mocs2
Mocs2tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 HMGU
IMPC		 8.90×10-06
Elk4
Elk4tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
EuroPhenome		 1.18×10-05
Tmem94
Tmem94tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 ICS
EuroPhenome		 1.78×10-05
Sbsn
Sbsnem1(IMPC)Ccpcz 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 CCP-IMG
IMPC		 1.81×10-05
Kmt2d
Kmt2dtm1.2(IMPC)Wtsi 		HET   Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
IMPC		 2.58×10-05
Slc35f5
Slc35f5em1(IMPC)Hmgu 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 HMGU
IMPC		 2.73×10-05
Tpcn2
Tpcn2Gt(YHD437)Byg 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 MRC Harwell
EuroPhenome		 3.08×10-05
Kctd10
Kctd10Gt(RRG305)Byg 		HET   Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 WTSI
MGP		 4.21×10-05
Vmp1
Vmp1not yet available 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 HMGU
EuroPhenome		 5.77×10-05
Hycc1
Hycc1em1(IMPC)Ccpcz 		HOM   Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 CCP-IMG
IMPC		 6.30×10-05
Svep1
Svep1tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 JAX
IMPC		 6.69×10-05
Bms1
Bms1tm1b(EUCOMM)Hmgu 		HET   Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 HMGU
IMPC		 9.26×10-05
Abca16
Abca16em1(IMPC)J 		HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry		 JAX
IMPC		 9.86×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Terminal Bleed
Urine Analysis

 Phenotype associations stats

0.78% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating sodium level (29/3705)

0.27% females (10/3658) 0.44% males (16/3632)

Select a parameter    



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