Phenotype: decreased circulating sodium level

Definition
less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume
Synonyms
hyponatremia,  reduced circulating sodium level,  hyponatraemia
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased circulating sodium level

Total number of significant genotype-phenotype associations: 28

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Dll1
Dll1tm1Gos
HET   Early adult decreased circulating sodium level Sodium
Clinical chemistry (GMC)
HMGU
EuroPhenome
1.00×10-12
Abcg8
Abcg8tm1b(KOMP)Wtsi
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
CCP-IMG
IMPC
2.78×10-10
Unc80
Unc80em1(IMPC)Tcp
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
TCP
IMPC
6.03×10-08
Farsa
Farsatm2a(EUCOMM)Wtsi
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
IMPC
2.30×10-07
Aldh16a1
Aldh16a1tm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
IMPC
5.62×10-07
Nfkb1
Nfkb1tm1a(KOMP)Wtsi
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
EuroPhenome
5.87×10-07
Trim9
Trim9em1(IMPC)Ccpcz
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
CCP-IMG
IMPC
7.96×10-07
Polr2h
Polr2htm1.1(KOMP)Wtsi
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
JAX
IMPC
2.25×10-06
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
ICS
EuroPhenome
2.76×10-06
Ndufa8
Ndufa8tm1a(EUCOMM)Hmgu
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
HMGU
EuroPhenome
3.99×10-06
Plet1
Plet1em1(IMPC)Wtsi
HOM   Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
IMPC
4.27×10-06
Art1
Art1tm1b(EUCOMM)Wtsi
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
TCP
IMPC
4.95×10-06
Secisbp2
Secisbp2tm1a(EUCOMM)Wtsi
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
EuroPhenome
4.99×10-06
Asb5
Asb5em1(IMPC)Ccpcz
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
CCP-IMG
IMPC
5.02×10-06
Cyrib
Cyribtm1b(KOMP)Wtsi
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
TCP
IMPC
5.79×10-06
Mocs2
Mocs2tm1b(EUCOMM)Wtsi
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
HMGU
IMPC
8.90×10-06
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
EuroPhenome
1.18×10-05
Tmem94
Tmem94tm1a(EUCOMM)Wtsi
HET   Early adult decreased circulating sodium level Sodium
Clinical Chemistry
ICS
EuroPhenome
1.78×10-05
Sbsn
Sbsnem1(IMPC)Ccpcz
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
CCP-IMG
IMPC
1.81×10-05
Slc35f5
Slc35f5em1(IMPC)Hmgu
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
HMGU
IMPC
1.85×10-05
Kmt2d
Kmt2dtm1.2(IMPC)Wtsi
HET   Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
IMPC
2.58×10-05
Tpcn2
Tpcn2Gt(YHD437)Byg
HOM Early adult decreased circulating sodium level Sodium
Clinical Chemistry
MRC Harwell
EuroPhenome
3.08×10-05
Kctd10
Kctd10Gt(RRG305)Byg
HET   Early adult decreased circulating sodium level Sodium
Clinical Chemistry
WTSI
MGP
4.21×10-05
Vmp1
Vmp1not yet available
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
HMGU
EuroPhenome
5.77×10-05
Fam126a
Fam126aem1(IMPC)Ccpcz
HOM   Early adult decreased circulating sodium level Sodium
Clinical Chemistry
CCP-IMG
IMPC
6.30×10-05
Svep1
Svep1tm1b(EUCOMM)Hmgu
HET Early adult decreased circulating sodium level Sodium
Clinical Chemistry
JAX
IMPC
6.69×10-05
Bms1
Bms1tm1b(EUCOMM)Hmgu
HET   Early adult decreased circulating sodium level Sodium
Clinical Chemistry
HMGU
IMPC
9.26×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.64% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating sodium level (27/4223)

0.23% females (8/3524) 0.37% males (13/3506)

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