IMPC Gene variants with decreased B cell number
Total number of significant genotype-phenotype associations: 72
Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
---|---|---|---|---|---|---|---|
Aicda Aicdatm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased follicular B cell number | Follicular B cells - % of B2 cells Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Aicda Aicdatm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased late germinal center B cell number | Late germinal centre B cells - % of GC cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Arhgap17 Arhgap17tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased B-1a cell number | B1a cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Arhgap17 Arhgap17tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased follicular B cell number | Follicular B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Arhgap17 Arhgap17tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased mature B cell number | IgD+ mature B cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Arhgef1 Arhgef1tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased marginal zone B cell number | Marginal zone B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Arpc1b Arpc1btm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased marginal zone precursor B cell number | Marginal zone precursor B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Arpc1b Arpc1btm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased transitional stage T2 B cell number | Transitional 2 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Bach2 Bach2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased mature B cell number | Mature B cells (Hardy fraction F) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
Bach2 Bach2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased follicular B cell number | Follicular B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Bach2 Bach2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased B cell number | B cell number Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased marginal zone B cell number | Marginal zone B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased transitional stage T2 B cell number | Transitional 2 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Cttnbp2 Cttnbp2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased immature B cell number | Immature B cells (Hardy fraction E) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased mature B cell number | Mature B cells (Hardy fraction F) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased pre-B cell number | Pre-B cells (Hardy fraction D) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased B cell number | B cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Dph6 Dph6tm1a(KOMP)Wtsi |
HOM | Early adult | decreased mature B cell number | IgD+ mature B cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased immature B cell number | Immature B cells (Hardy fraction E) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased follicular B cell number | Follicular B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased B-2 B cell number | Total B2 cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased B cell number | B cell number Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased mature B cell number | IgD+ mature B cell number Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Gm5544 Gm5544tm1a(KOMP)Wtsi |
HET | Early adult | decreased marginal zone B cell number | Marginal zone B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T2 B cell number | Transitional 2 B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Hbs1l Hbs1ltm1a(KOMP)Wtsi |
HOM | Early adult | decreased mature B cell number | Mature B cells (Hardy fraction F) - % of CD45+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
Mysm1 Mysm1tm1a(KOMP)Wtsi |
HOM | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
HMGU EuroPhenome |
0.00 | |
Mysm1 Mysm1tm1a(KOMP)Wtsi |
HOM | Early adult | decreased mature B cell number | Mature B cells IgD+ percentage FACs Analysis |
HMGU EuroPhenome |
0.00 | |
Pepd Pepdtm1a(KOMP)Wtsi |
HOM | Early adult | decreased immature B cell number | Immature B cells (Hardy fraction E) - % of B220+ Bone marrow immunophenotyping |
WTSI 3i |
0.00 | |
Pepd Pepdtm1a(KOMP)Wtsi |
HOM | Early adult | decreased transitional stage T1 B cell number | Transitional 1 B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased early germinal center B cell number | Early germinal centre B cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased germinal center B cell number | Germinal centre B cells - % of B2 cells Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Tmem127 Tmem127tm1(KOMP)Wtsi |
HOM | Early adult | decreased B cell number | Total B cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Tmem127 Tmem127tm1(KOMP)Wtsi |
HOM | Early adult | decreased B-2 B cell number | Total B2 cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Ric1 Ric1tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
2.11×10-14 | |
Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased B-2 B cell number | B2B Cells Immunophenotyping |
HMGU IMPC |
2.22×10-11 | |
Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased B cell number | B Cells Immunophenotyping |
HMGU IMPC |
3.53×10-11 | |
Abcg8 Abcg8tm1b(KOMP)Wtsi |
HOM | Early adult | decreased B-2 B cell number | B2B Cells Immunophenotyping |
CCP-IMG IMPC |
9.67×10-11 | |
Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased follicular B cell number | Follicular B Cells (CD21/35+) Immunophenotyping |
HMGU IMPC |
1.68×10-10 | |
Rhbdd1 Rhbdd1tm1.1Mfm |
HOM | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
2.66×10-10 | |
Pknox1 Pknox1Gt(EUCJ0079d10)Hmgu |
HET | Early adult | decreased mature B cell number | Mature B cells IgD+ percentage FACs Analysis |
HMGU EuroPhenome |
6.01×10-08 | |
Plcg2 Plcg2Ali14 |
HET | Early adult | decreased mature B cell number | Mature B cells IgD+ percentage FACs Analysis |
HMGU EuroPhenome |
7.70×10-08 | |
Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased marginal zone B cell number | MZB (CD21/35 high) Immunophenotyping |
HMGU IMPC |
9.79×10-08 | |
Btk Btktm1a(EUCOMM)Hmgu |
HEM | Early adult | decreased mature B cell number | Mature B cells IgD+ percentage FACs Analysis |
ICS EuroPhenome |
3.91×10-06 | |
B4galnt3 B4galnt3tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
ICS EuroPhenome |
5.62×10-06 | |
Elmod1 Elmod1tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
9.72×10-06 | |
Nfkbid Nfkbidtm1a(EUCOMM)Wtsi |
HET | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
HMGU EuroPhenome |
1.05×10-05 | |
Pepd Pepdtm1b(KOMP)Wtsi |
HOM | Late adult | decreased follicular B cell number | Follicular B Cells (CD21/35+) Immunophenotyping |
HMGU IMPC |
1.07×10-05 | |
Elk4 Elk4tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased mature B cell number | Mature B cells IgD+ percentage FACs Analysis |
HMGU EuroPhenome |
1.47×10-05 | |
Pepd Pepdtm1b(KOMP)Wtsi |
HOM | Late adult | decreased B cell number | B Cells Immunophenotyping |
HMGU IMPC |
1.73×10-05 | |
Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased transitional stage B cell number | Transitional B Cells (CD21/35 low) Immunophenotyping |
HMGU IMPC |
1.86×10-05 | |
Pepd Pepdtm1b(KOMP)Wtsi |
HOM | Late adult | decreased B-2 B cell number | B2B Cells Immunophenotyping |
HMGU IMPC |
1.91×10-05 | |
Rhbdf2 Rhbdf2Rhbdf2 |
HOM | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
3.01×10-05 | |
Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased B-1a cell number | B1B Cells Immunophenotyping |
HMGU IMPC |
3.10×10-05 | |
Pknox1 Pknox1Gt(EUCJ0079d10)Hmgu |
HET | Early adult | decreased B cell number | B cell CD19+ percentage FACs Analysis |
HMGU EuroPhenome |
4.72×10-05 | |
Pla2g10 Pla2g10tm1a(EUCOMM)Hmgu |
HET | Early adult | decreased mature B cell number | Mature B cells IgD+ percentage FACs Analysis |
HMGU EuroPhenome |
6.98×10-05 |