IMPC Gene variants with decreased regulatory T cell number
Total number of significant genotype-phenotype associations: 18
Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
---|---|---|---|---|---|---|---|
Bach2 Bach2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased regulatory T cell number | CD4+ CD25+ alpha beta regulatory T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Resting Treg cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Effector Treg cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Total Treg cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased regulatory T cell number | CD4+ CD25+ alpha beta regulatory T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Ncf2 Ncf2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased regulatory T cell number | CD4+ CD25+ alpha beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Pclaf Pclaftm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased regulatory T cell number | CD4+ CD25+ alpha beta regulatory T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Rwdd1 Rwdd1tm1b(KOMP)Wtsi |
HOM | Early adult | decreased regulatory T cell number | CD4+ CD25+ alpha beta regulatory T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased regulatory T cell number | CD4+ CD25+ alpha beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Trim56 Trim56tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased regulatory T cell number | CD4+ CD25+ alpha beta regulatory T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Card11 Card11em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Treg cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
3.18×10-36 | |
Cd38 Cd38em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Treg cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
4.30×10-20 | |
Cd27 Cd27em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Treg cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
2.16×10-07 |