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Phenotype: abnormal regulatory T cell number

Definition
deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
Synonyms
abnormal Treg cell number,  abnormal suppressor T cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal regulatory T cell number

Total number of significant genotype-phenotype associations: 47

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cttnbp2
Cttnbp2tm1b(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM Early adult decreased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM Early adult increased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Il27
Il27tm1b(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Ncf2
Ncf2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Pclaf
Pclaftm1a(EUCOMM)Wtsi 		HOM Early adult decreased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Rwdd1
Rwdd1tm1b(KOMP)Wtsi 		HOM Early adult decreased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Setd5
Setd5tm1a(EUCOMM)Wtsi 		HET Early adult increased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD4+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM Early adult decreased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Trim56
Trim56tm1a(EUCOMM)Wtsi 		HOM Early adult decreased regulatory T cell number CD4+ CD25+ alpha beta regulatory T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Card11
Card11em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.18×10-36
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.30×10-20
Fam83h
Fam83hem1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.22×10-08
Cd27
Cd27em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.16×10-07
Mmp20
Mmp20em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.39×10-06
Spred1
Spred1em1(IMPC)Ccpcz 		HOM   Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 9.48×10-06
Ltn1
Ltn1tm1b(EUCOMM)Hmgu 		HOM Early adult increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.87×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

3.02% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal regulatory T cell number (24/796)

2.67% females (9/337) 3.56% males (12/337)

Select a parameter    



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