Phenotype: abnormal vertebral arch morphology

Definition
any structural anomaly of the dorsal bony and/or cartilaginous part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)
Synonyms
abnormal neural arch morphology,  abnormal dorsal arch morphology
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal vertebral arch morphology

Total number of significant genotype-phenotype associations: 18

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM postnatal abnormal vertebral arch morphology X-ray | Lumbar processes WTSI | IMPC 3.62×10-19
Phex
Phexnot yet available
HOM postnatal abnormal vertebral arch morphology X-Ray | Processes on vertebrae HMGU | EuroPhenome 4.04×10-08
Aff3
Aff3tm1a(EUCOMM)Wtsi
HET postnatal abnormal vertebral arch morphology X-ray | Thoracic processes WTSI | IMPC 6.83×10-08
Cbx5
Cbx5tm1a(EUCOMM)Wtsi
HOM postnatal fusion of vertebral arches X-ray | Fusion of processes WTSI | IMPC 7.07×10-08
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM postnatal fusion of vertebral arches X-ray | Fusion of processes WTSI | IMPC 2.42×10-07
Wdr37
Wdr37tm1a(KOMP)Wtsi
HOM postnatal fusion of vertebral arches X-ray | Fusion of processes WTSI | IMPC 2.42×10-07
Aff3
Aff3tm1a(EUCOMM)Wtsi
HOM postnatal abnormal vertebral arch morphology X-ray | Thoracic processes WTSI | IMPC 3.27×10-07
Spopl
Spopltm1a(EUCOMM)Wtsi
HOM postnatal abnormal vertebral arch morphology X-ray | Thoracic processes WTSI | IMPC 4.54×10-06
Aff3
Aff3tm1a(EUCOMM)Wtsi
HOM postnatal fusion of vertebral arches X-ray | Fusion of processes WTSI | IMPC 6.44×10-06
Mysm1
Mysm1tm1a(KOMP)Wtsi
HET postnatal abnormal vertebral arch morphology X-Ray | Processes on vertebrae WTSI | EuroPhenome 1.42×10-05
Skida1
Skida1tm1(KOMP)Wtsi
HET postnatal abnormal vertebral arch morphology X-ray | Thoracic processes WTSI | IMPC 1.71×10-05
Slc25a30
Slc25a30tm1a(EUCOMM)Wtsi
HOM postnatal abnormal vertebral arch morphology X-ray | Thoracic processes WTSI | IMPC 1.71×10-05
Epc2
Epc2tm1e(EUCOMM)Wtsi
HET postnatal abnormal vertebral arch morphology X-Ray | Processes on vertebrae WTSI | EuroPhenome 4.47×10-05
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM postnatal fusion of vertebral arches X-ray | Fusion of processes WTSI | IMPC 4.96×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
X-Ray
X-ray

 Phenotype associations stats

0.31% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal vertebral arch morphology (12/3826)

0.21% females (8/3787) 0.21% males (8/3807)

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