Phenotype: decreased heart rate variability

Definition
reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle
Synonyms
decreased respiratory sinus arrhythmia
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart rate variability

Total number of significant genotype-phenotype associations: 56

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Alkbh8
Alkbh8tm1b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
6.47×10-27
Ppp2r2b
Ppp2r2btm1b(KOMP)Wtsi
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
7.09×10-27
C7
C7em1(IMPC)J
HOM Late adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
1.12×10-12
Gramd1c
Gramd1ctm1b(KOMP)Wtsi
HOM Late adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
8.15×10-10
Sgip1
Sgip1tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
9.38×10-10
Casq2
Casq2tm1b(KOMP)Wtsi
HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
3.42×10-09
Rps26
Rps26tm2b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
1.85×10-08
Hsf4
Hsf4tm1b(KOMP)Wtsi
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
3.87×10-08
Spink13
Spink13em1(IMPC)Ccpcz
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
CCP-IMG
IMPC
8.64×10-08
Edc3
Edc3em1(IMPC)Tcp
HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
2.76×10-07
Gja8
Gja8tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.46×10-07
Rsf1
Rsf1tm1b(EUCOMM)Wtsi
HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
3.65×10-07
Agl
Agltm1b(EUCOMM)Wtsi
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
MRC Harwell
IMPC
5.35×10-07
Chst14
Chst14em1(IMPC)Tcp
HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
7.20×10-07
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
7.88×10-07
Fam161a
Fam161atm1b(KOMP)Wtsi
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
8.95×10-07
Far2
Far2tm2b(KOMP)Wtsi
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
1.00×10-06
Apbb1ip
Apbb1ipem1(IMPC)Ccpcz
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
CCP-IMG
IMPC
1.17×10-06
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
1.60×10-06
Lactb
Lactbtm1.1(KOMP)Mbp
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
2.17×10-06
1700086L19Rik
1700086L19Riktm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
BCM
IMPC
2.57×10-06
Aif1
Aif1tm1.1(KOMP)Wtsi
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
3.29×10-06
Atp8b1
Atp8b1em1(IMPC)Tcp
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
3.71×10-06
Atrip
Atriptm1b(KOMP)Wtsi
HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
4.92×10-06
Fam162a
Fam162atm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
4.95×10-06
Chtf18
Chtf18tm1b(KOMP)Wtsi
HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
6.03×10-06
Ptprv
Ptprvtm1b(NCOM)Mfgc
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
1.20×10-05
Elof1
Elof1tm1.1(KOMP)Vlcg
HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
1.20×10-05
Dnajc5g
Dnajc5gtm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
1.62×10-05
Zfp275
Zfp275tm1.1(NCOM)Mfgc
HEM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
1.73×10-05
Fbxo10
Fbxo10em1(IMPC)J
HOM Late adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
1.83×10-05
C9
C9tm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
1.89×10-05
Ism2
Ism2tm3b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
BCM
IMPC
2.16×10-05
Ciao2b
Ciao2bem1(IMPC)Ccpcz
HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
CCP-IMG
IMPC
2.40×10-05
Mrps22
Mrps22tm1.1(KOMP)Vlcg
HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
2.46×10-05
Mamld1
Mamld1tm1.1(NCOM)Mfgc
HEM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
2.62×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
2.63×10-05
Eif4enif1
Eif4enif1em1(IMPC)Tcp
HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
2.64×10-05
Tas2r116
Tas2r116em1(IMPC)Bay
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
BCM
IMPC
2.70×10-05
Slc44a4
Slc44a4tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
3.16×10-05
Atp6v0d1
Atp6v0d1tm1b(EUCOMM)Hmgu
HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
3.38×10-05
Lrp1
Lrp1tm1.1(KOMP)Wtsi
HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
3.47×10-05
Drc7
Drc7em1(IMPC)J
HOM Late adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
3.48×10-05
Klkb1
Klkb1tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
3.48×10-05
Tuba8
Tuba8em1(IMPC)J
HOM   Late adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
4.24×10-05
Prdm14
Prdm14em1(IMPC)Bay
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
BCM
IMPC
4.66×10-05
Serpinb5
Serpinb5tm1b(KOMP)Wtsi
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
5.36×10-05
Nagk
Nagktm1b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
MRC Harwell
IMPC
8.54×10-05
Ctla2b
Ctla2btm1.1(NCOM)Mfgc
HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
TCP
IMPC
9.40×10-05
Hdac1
Hdac1tm1b(EUCOMM)Wtsi
HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
HMGU
IMPC
9.47×10-05
Vsig8
Vsig8tm1.1(KOMP)Mbp
HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)
JAX
IMPC
9.69×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

1.99% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate variability (51/2569)

0.91% females (23/2514) 0.44% males (11/2508)

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