Phenotype: decreased heart rate variability

Definition
reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle
Synonyms
decreased respiratory sinus arrhythmia
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart rate variability

Total number of significant genotype-phenotype associations: 56

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Sgip1
Sgip1tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 0.00
Alkbh8
Alkbh8tm1b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 2.67×10-28
Ppp2r2b
Ppp2r2btm1b(KOMP)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 2.04×10-17
C7
C7em1(IMPC)J
HOM Late adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 8.89×10-13
Casq2
Casq2tm1b(KOMP)Wtsi
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 2.78×10-11
Agl
Agltm1b(EUCOMM)Wtsi
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV MRC Harwell | IMPC 1.91×10-08
Rps26
Rps26tm2b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 2.05×10-08
Hsf4
Hsf4tm1b(KOMP)Wtsi
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 3.72×10-08
Rsf1
Rsf1tm1b(EUCOMM)Wtsi
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 5.08×10-08
Aif1
Aif1tm1.1(KOMP)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 1.11×10-07
Spink13
Spink13em1(IMPC)Ccpcz
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV CCP-IMG | IMPC 3.07×10-07
Lactb
Lactbtm1.1(KOMP)Mbp
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 4.55×10-07
Gja8
Gja8tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV MRC Harwell | IMPC 5.03×10-07
Fam161a
Fam161atm1b(KOMP)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 6.93×10-07
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 8.32×10-07
Far2
Far2tm2b(KOMP)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 2.02×10-06
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 2.52×10-06
1700086L19Rik
1700086L19Riktm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV BCM | IMPC 2.58×10-06
C9
C9tm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 3.70×10-06
Ciao2b
Ciao2bem1(IMPC)Ccpcz
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV CCP-IMG | IMPC 3.79×10-06
Vsig8
Vsig8tm1.1(KOMP)Mbp
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 5.54×10-06
Chtf18
Chtf18tm1b(KOMP)Wtsi
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 6.33×10-06
Fam162a
Fam162atm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 7.32×10-06
Atrip
Atriptm1b(KOMP)Wtsi
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 9.28×10-06
Mmaa
Mmaaem1(IMPC)J
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 1.06×10-05
Elof1
Elof1tm1.1(KOMP)Vlcg
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 1.54×10-05
Fbxo10
Fbxo10em1(IMPC)J
HOM Late adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 1.56×10-05
Dnajc5g
Dnajc5gtm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 1.93×10-05
Slc44a4
Slc44a4tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 2.02×10-05
Ism2
Ism2tm3b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV BCM | IMPC 2.20×10-05
Cldn13
Cldn13tm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 2.34×10-05
Klkb1
Klkb1tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 2.58×10-05
Tas2r116
Tas2r116em1(IMPC)Bay
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV BCM | IMPC 2.67×10-05
Serpinb5
Serpinb5tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 2.89×10-05
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV MRC Harwell | IMPC 3.13×10-05
Atp8b1
Atp8b1em1(IMPC)Tcp
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 3.58×10-05
Edc3
Edc3em1(IMPC)Tcp
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 3.68×10-05
Nagk
Nagktm1b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV MRC Harwell | IMPC 4.07×10-05
Hpse
Hpsetm1b(EUCOMM)Hmgu
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 4.27×10-05
Mrps22
Mrps22tm1.1(KOMP)Vlcg
HET Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 4.31×10-05
Lrp1
Lrp1tm1.1(KOMP)Wtsi
HET   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 4.38×10-05
Tuba8
Tuba8em1(IMPC)J
HOM   Late adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 4.66×10-05
Prdm14
Prdm14em1(IMPC)Bay
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV BCM | IMPC 4.66×10-05
Drc7
Drc7em1(IMPC)J
HOM Late adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 5.24×10-05
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV JAX | IMPC 6.23×10-05
Chst14
Chst14em1(IMPC)Tcp
HET   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 7.04×10-05
Gsta4
Gsta4tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV HMGU | IMPC 7.13×10-05
Zfp275
Zfp275tm1.1(NCOM)Mfgc
HEM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 7.49×10-05
Mamld1
Mamld1tm1.1(NCOM)Mfgc
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 7.63×10-05
Eif4enif1
Eif4enif1em1(IMPC)Tcp
HET   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 7.91×10-05
Zfp275
Zfp275tm1.1(NCOM)Mfgc
HOM   Early adult decreased heart rate variability Electrocardiogram (ECG) | HRV TCP | IMPC 9.42×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

2.00% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate variability (50/2503)

0.94% females (23/2459) 0.57% males (14/2454)

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