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Phenotype: abnormal PR interval

Definition
anomaly in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal PR interval

Total number of significant genotype-phenotype associations: 29

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Cdk20
Cdk20em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 2.02×10-38
Shmt2
Shmt2em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 4.80×10-31
Eral1
Eral1em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 1.27×10-20
Usp53
Usp53em1(IMPC)Tcp 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 1.65×10-09
Pigq
Pigqtm2b(EUCOMM)Wtsi 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 1.69×10-08
Elmod1
Elmod1tm1b(EUCOMM)Hmgu 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 5.28×10-08
Cbl
Cbltm1b(EUCOMM)Hmgu 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 9.85×10-08
Cldn19
Cldn19tm1.1(KOMP)Vlcg 		HOM   Early adult shortened PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 1.81×10-06
Sorbs2
Sorbs2tm1.1(KOMP)Mbp 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 1.97×10-06
Il2ra
Il2ratm1b(EUCOMM)Wtsi 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 2.61×10-06
Iqca1
Iqca1em1(IMPC)J 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 5.91×10-06
Gnl1
Gnl1em1(IMPC)Tcp 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 8.85×10-06
Limd1
Limd1em1(IMPC)H 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.37×10-05
Rex1bd
Rex1bdem1(IMPC)J 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 3.72×10-05
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 3.88×10-05
Gpr150
Gpr150em1(IMPC)J 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 4.38×10-05
Tmem256
Tmem256tm1.1(KOMP)Vlcg 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 UC Davis
IMPC		 4.53×10-05
Cyp4b1
Cyp4b1tm1b(KOMP)Wtsi 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 HMGU
IMPC		 4.53×10-05
Snca
Sncaem1(IMPC)H 		HOM Late adult prolonged PR interval PR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 4.79×10-05
Rab33b
Rab33bem1(IMPC)J 		HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 4.99×10-05
Gpbp1
Gpbp1tm1b(EUCOMM)Wtsi 		HET Early adult shortened PR interval PR
Electrocardiogram (ECG)		 HMGU
IMPC		 4.99×10-05
Gxylt1
Gxylt1em1(IMPC)Bay 		HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 BCM
IMPC		 5.52×10-05
Synpo2
Synpo2tm1b(EUCOMM)Wtsi 		HET   Early adult prolonged PR interval PR
Electrocardiogram (ECG)		 ICS
IMPC		 6.97×10-05
Dnaaf1
Dnaaf1em1(IMPC)J 		HET Early adult shortened PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 7.30×10-05
Mrgprd
Mrgprdtm1b(EUCOMM)Hmgu 		HOM   Early adult shortened PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 7.53×10-05
Lbr
Lbrem1(IMPC)Tcp 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 TCP
IMPC		 8.89×10-05
Ociad1
Ociad1em1(IMPC)J 		HOM   Early adult shortened PR interval PR
Electrocardiogram (ECG)		 JAX
IMPC		 9.19×10-05
Zdhhc5
Zdhhc5tm1e.1(EUCOMM)Hmgu 		HOM Early adult shortened PR interval PR
Electrocardiogram (ECG)		 HMGU
IMPC		 9.82×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

0.47% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal PR interval (28/6012)

0.22% females (13/5972) 0.18% males (11/5963)

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