Phenotype: abnormal PR interval

Definition
anomaly in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal PR interval

Total number of significant genotype-phenotype associations: 86

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Focad
Focadem1(IMPC)Bay
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 7.22×10-09
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Early adult shortened PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 2.41×10-08
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR TCP | IMPC 3.39×10-08
Pbx3
Pbx3tm1b(EUCOMM)Wtsi
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 4.18×10-08
Cacna1f
Cacna1ftm1.1(KOMP)Vlcg
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 6.50×10-08
Ugt2a1
Ugt2a1em1(IMPC)Bay
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 1.69×10-07
Gpbp1
Gpbp1tm1b(EUCOMM)Wtsi
HET Early adult shortened PR interval Electrocardiogram (ECG) | PR HMGU | IMPC 6.29×10-07
Aoah
Aoahem1(IMPC)Mbp
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 8.98×10-07
Slc9a1
Slc9a1em1(IMPC)Mbp
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 1.08×10-06
Tnks
Tnksem1(IMPC)Hmgu
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR HMGU | IMPC 1.19×10-06
Fadd
Faddtm1e.1(KOMP)Wtsi
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR TCP | IMPC 3.17×10-06
Rnd2
Rnd2em1(IMPC)Mbp
HOM Early adult shortened PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 4.06×10-06
Rgs2
Rgs2em1(IMPC)H
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 4.21×10-06
Gm20498
Gm20498em1(IMPC)J
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 4.58×10-06
Rgs2
Rgs2em1(IMPC)H
HET Early adult prolonged PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 6.77×10-06
Klhdc2
Klhdc2tm1b(EUCOMM)Hmgu
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 8.47×10-06
Rab28
Rab28em1(IMPC)J
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 8.57×10-06
Dmp1
Dmp1tm1.1(KOMP)Vlcg
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 1.05×10-05
Acoxl
Acoxlem1(IMPC)Mbp
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 1.16×10-05
Ecpas
Ecpasem1(IMPC)J
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 1.45×10-05
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 1.46×10-05
Mindy4
Mindy4em1(IMPC)H
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 1.73×10-05
Smo
Smotm1b(KOMP)Wtsi
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 1.89×10-05
Padi4
Padi4em1(IMPC)Mbp
HOM Late adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 2.01×10-05
Plaur
Plaurem1(IMPC)H
HOM Late adult prolonged PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 2.10×10-05
Pkmyt1
Pkmyt1em1(IMPC)J
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 2.24×10-05
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 2.33×10-05
Usp22
Usp22tm1b(KOMP)Wtsi
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 2.56×10-05
Nmur1
Nmur1tm1.1(KOMP)Vlcg
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 2.60×10-05
Ythdc2
Ythdc2em1(IMPC)Bay
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 2.78×10-05
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 3.26×10-05
A930017K11Rik
A930017K11Riktm1b(KOMP)Wtsi
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 3.33×10-05
Rhobtb1
Rhobtb1em2(IMPC)Ccpcz
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR CCP-IMG | IMPC 3.99×10-05
Cyp4b1
Cyp4b1tm1b(KOMP)Wtsi
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR HMGU | IMPC 4.26×10-05
Nnat
Nnatem1(IMPC)Mbp
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 4.74×10-05
Papln
Paplntm1b(KOMP)Wtsi
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 5.04×10-05
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 5.06×10-05
Trdmt1
Trdmt1tm1b(EUCOMM)Hmgu
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 5.10×10-05
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 5.14×10-05
Prex2
Prex2em1(IMPC)Bay
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 5.17×10-05
Scd3
Scd3em1(IMPC)Bay
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 5.32×10-05
Grik4
Grik4em1(IMPC)Mbp
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 5.43×10-05
Spata31d1d
Spata31d1dem1(IMPC)J
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 5.50×10-05
Trappc2
Trappc2tm1.1(KOMP)Vlcg
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 6.12×10-05
Snca
Sncaem1(IMPC)H
HOM Late adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 6.37×10-05
Gkap1
Gkap1tm2b(EUCOMM)Hmgu
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR BCM | IMPC 6.70×10-05
Hcn1
Hcn1em1(IMPC)H
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 7.91×10-05
Ints10
Ints10tm1b(KOMP)Wtsi
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 7.98×10-05
Kcnv1
Kcnv1em1(IMPC)J
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR JAX | IMPC 8.43×10-05
Gdf15
Gdf15tm1b(KOMP)Wtsi
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 8.69×10-05
Zfp69
Zfp69tm1b(EUCOMM)Hmgu
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR HMGU | IMPC 8.77×10-05
Osbpl5
Osbpl5em1(IMPC)J
HOM Early adult prolonged PR interval Electrocardiogram (ECG) | PR JAX | IMPC 9.07×10-05
Hcn1
Hcn1em1(IMPC)H
HOM Early adult prolonged PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 9.09×10-05
Kbtbd7
Kbtbd7tm1.1(KOMP)Vlcg
HOM Early adult prolonged PR interval Electrocardiogram (ECG) | PR JAX | IMPC 9.34×10-05
Il20rb
Il20rbem2(IMPC)Mbp
HOM Early adult abnormal PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 9.82×10-05
L3mbtl3
L3mbtl3em2(IMPC)Tcp
HET Early adult abnormal PR interval Electrocardiogram (ECG) | PR TCP | IMPC 9.92×10-05

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 The way we measure

 Phenotype associations stats

1.30% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal PR interval (54/4139)

0.59% females (24/4051) 0.20% males (8/4041)

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