Phenotype: abnormal ST segment

Definition
anomaly in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal ST segment

Total number of significant genotype-phenotype associations: 74

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Rrad
Rradtm1.1(KOMP)Vlcg
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 2.15×10-11
Gnb2
Gnb2em1(IMPC)J
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.03×10-10
Pitx3
Pitx3tm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.35×10-08
Trip13
Trip13tm1.1(KOMP)Vlcg
HET Early adult shortened ST segment Electrocardiogram (ECG) | ST JAX | IMPC 2.45×10-08
Rundc3a
Rundc3atm1b(EUCOMM)Wtsi
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST BCM | IMPC 2.71×10-08
Dnajc5b
Dnajc5btm1b(EUCOMM)Hmgu
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST ICS | IMPC 5.03×10-08
Iah1
Iah1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged ST segment Electrocardiogram (ECG) | ST ICS | IMPC 5.87×10-08
Laptm4a
Laptm4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged ST segment Electrocardiogram (ECG) | ST ICS | IMPC 9.57×10-08
Zfp395
Zfp395tm1b(EUCOMM)Wtsi
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST BCM | IMPC 1.12×10-07
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 5.03×10-07
Zfp395
Zfp395tm1b(EUCOMM)Wtsi
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST BCM | IMPC 8.13×10-07
Nfat5
Nfat5tm1b(KOMP)Wtsi
HET Early adult prolonged ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.09×10-06
Ace
Acetm1.1(KOMP)Vlcg
HET Early adult abnormal ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 1.10×10-06
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.64×10-06
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.76×10-06
Loxl1
Loxl1tm1.1(KOMP)Vlcg
HET Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.88×10-06
Cpt1c
Cpt1ctm1b(EUCOMM)Wtsi
HOM Early adult prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 2.55×10-06
Vsig8
Vsig8tm1.1(KOMP)Mbp
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 2.97×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST CCP-IMG | IMPC 4.38×10-06
Dipk2b
Dipk2bem1(IMPC)Mbp
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 4.65×10-06
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST JAX | IMPC 4.97×10-06
Rrad
Rradtm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST JAX | IMPC 5.70×10-06
Carf
Carftm1.1(KOMP)Vlcg
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 6.78×10-06
Sowaha
Sowahaem1(IMPC)Mbp
HOM Early adult prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 7.97×10-06
Toporsl
Toporsltm1.1(KOMP)Vlcg
HOM Early adult prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 8.42×10-06
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HET Early adult abnormal ST segment Electrocardiogram (ECG) | ST ICS | IMPC 9.28×10-06
Dennd2c
Dennd2ctm1b(KOMP)Wtsi
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 9.91×10-06
Col20a1
Col20a1em1(IMPC)Mbp
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 1.00×10-05
Ace
Acetm1.1(KOMP)Vlcg
HET Early adult prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 1.14×10-05
Ebf2
Ebf2em1(IMPC)Mbp
HET Early adult shortened ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 1.42×10-05
Pja2
Pja2tm1b(EUCOMM)Wtsi
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST BCM | IMPC 1.47×10-05
Hnrnpc
Hnrnpctm1b(EUCOMM)Hmgu
HET Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 1.89×10-05
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST ICS | IMPC 1.92×10-05
Dennd2c
Dennd2ctm1b(KOMP)Wtsi
HOM Early adult prolonged ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 1.96×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged ST segment Electrocardiogram (ECG) | ST JAX | IMPC 2.17×10-05
Pcdh18
Pcdh18tm1.1(KOMP)Vlcg
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 2.22×10-05
Mical3
Mical3em1(IMPC)J
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 2.66×10-05
Sh3tc1
Sh3tc1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST ICS | IMPC 2.68×10-05
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 3.60×10-05
Gnb2
Gnb2em1(IMPC)J
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST JAX | IMPC 4.01×10-05
Tmem256
Tmem256tm1.1(KOMP)Vlcg
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 4.43×10-05
Slc46a1
Slc46a1tm1b(KOMP)Mbp
HET Early adult prolonged ST segment Electrocardiogram (ECG) | ST JAX | IMPC 5.14×10-05
Paqr6
Paqr6tm1b(KOMP)Wtsi
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST BCM | IMPC 5.96×10-05
Ncald
Ncaldtm1.1(KOMP)Vlcg
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST JAX | IMPC 7.42×10-05
Klf12
Klf12tm1b(EUCOMM)Wtsi
HET Early adult abnormal ST segment Electrocardiogram (ECG) | ST ICS | IMPC 7.80×10-05
Igfbp3
Igfbp3tm1b(KOMP)Wtsi
HOM Early adult shortened ST segment Electrocardiogram (ECG) | ST MRC Harwell | IMPC 8.17×10-05
Rbm20
Rbm20em1(IMPC)Mbp
HOM Early adult abnormal ST segment Electrocardiogram (ECG) | ST UC Davis | IMPC 8.41×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

1.07% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal ST segment (39/3628)

0.36% females (13/3571) 0.56% males (20/3569)



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