Phenotype: abnormal cardiac output

Definition
anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal cardiac output

Total number of significant genotype-phenotype associations: 34

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult abnormal cardiac output Echo | Cardiac Output BCM | IMPC 4.56×10-11
Nr1d1
Nr1d1tm1(KOMP)Vlcg
HOM Early adult abnormal cardiac output Echo | Cardiac Output BCM | IMPC 5.22×10-10
Nek1
Nek1em1(IMPC)Bay
HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 9.50×10-09
Nr1d1
Nr1d1tm1(KOMP)Vlcg
HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 1.37×10-08
Golt1b
Golt1btm1b(EUCOMM)Wtsi
HOM Early adult decreased cardiac output Echo | Cardiac Output HMGU | IMPC 1.42×10-08
Rps6kc1
Rps6kc1tm1b(EUCOMM)Wtsi
HOM Early adult abnormal cardiac output Echo | Cardiac Output BCM | IMPC 7.52×10-08
Lrrfip1
Lrrfip1tm1.1(KOMP)Wtsi
HOM Early adult abnormal cardiac output Echo | Cardiac Output BCM | IMPC 1.66×10-07
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 1.17×10-06
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu
HET Early adult abnormal cardiac output Echo | Cardiac Output HMGU | IMPC 1.26×10-06
Kcns2
Kcns2em1(IMPC)Bay
HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 2.43×10-06
Shox2
Shox2em1(IMPC)Bay
HET Early adult abnormal cardiac output Echo | Cardiac Output BCM | IMPC 5.27×10-06
Map3k12
Map3k12tm1b(EUCOMM)Hmgu
HET Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 5.72×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu
HOM Early adult abnormal cardiac output Echo | Cardiac Output HMGU | IMPC 9.47×10-06
Pcdh20
Pcdh20em1(IMPC)H
HOM Late adult abnormal cardiac output Echo | Cardiac Output MRC Harwell | IMPC 1.55×10-05
Ces1a
Ces1atm1b(KOMP)Wtsi
HOM Early adult increased cardiac output Echo | Cardiac Output BCM | IMPC 1.81×10-05
AW549877
AW549877tm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac output Echo | Cardiac Output BCM | IMPC 2.37×10-05
Ces1a
Ces1atm1b(KOMP)Wtsi
HOM Early adult abnormal cardiac output Echo | Cardiac Output BCM | IMPC 2.89×10-05
Vgll4
Vgll4tm1b(EUCOMM)Hmgu
HET Early adult abnormal cardiac output Echo | Cardiac Output HMGU | IMPC 3.39×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult abnormal cardiac output Echo | Cardiac Output BCM | IMPC 4.56×10-05
Col11a2
Col11a2tm1b(KOMP)Wtsi
HET Early adult abnormal cardiac output Echo | Cardiac Output HMGU | IMPC 6.89×10-05
Ndrg4
Ndrg4tm1b(KOMP)Wtsi
HOM Early adult abnormal cardiac output Echo | Cardiac Output MRC Harwell | IMPC 9.44×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.46% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal cardiac output (18/1231)

0.67% females (8/1196) 0.86% males (8/929)

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