MP:0001627 (abnormal cardiac output) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: abnormal cardiac output

Definition

anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 10

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Nr1d1 Nr1d1^{tm1(KOMP)Vlcg}	HOM	Early adult	decreased cardiac output	Cardiac Output Echo	BCM IMPC	5.22×10^-10
Psd3 Psd3^em1(IMPC)H	HOM	Late adult	increased cardiac output	Cardiac Output Echo	MRC Harwell IMPC	6.51×10^-10
Ces1a Ces1a^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased cardiac output	Cardiac Output Echo	BCM IMPC	1.24×10^-06
Hycc1 Hycc1^{em1(IMPC)Ccpcz}	HOM	Early adult	increased cardiac output	Cardiac Output Echo	CCP-IMG IMPC	3.89×10^-06
Golt1b Golt1b^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	decreased cardiac output	Cardiac Output Echo	HMGU IMPC	7.26×10^-06
Col11a2 Col11a2^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased cardiac output	Cardiac Output Echo	HMGU IMPC	2.78×10^-05
Man2a1 Man2a1^{em1(IMPC)Hmgu}	HOM	Early adult	increased cardiac output	Cardiac Output Echo	HMGU IMPC	3.44×10^-05
Zfp300 Zfp300^em1(IMPC)Bay	HOM	Early adult	increased cardiac output	Cardiac Output Echo	BCM IMPC	4.60×10^-05
Ap4e1 Ap4e1^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased cardiac output	Cardiac Output Echo	BCM IMPC	6.31×10^-05
Vars2 Vars2^em1(IMPC)Bay	HET	Early adult	increased cardiac output	Cardiac Output Echo	BCM IMPC	6.55×10^-05

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Procedure
Echo

0.54% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal cardiac output (10/1835)

0.22% females (4/1817) 0.39% males (6/1535)

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