Phenotype: syndactyly

Definition
any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with syndactyly

Total number of significant genotype-phenotype associations: 25

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Fuz
Fuzem1(IMPC)Mbp
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly UC Davis | IMPC 0.00
Grhl2
Grhl2em1(IMPC)Mbp
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly UC Davis | IMPC 0.00
Rgl1
Rgl1em1(IMPC)Mbp
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly UC Davis | IMPC 0.00
Snx3
Snx3tm1.1(KOMP)Vlcg
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly JAX | IMPC 0.00
Snx3
Snx3tm1.1(KOMP)Vlcg
HOM E18.5 syndactyly Gross Morphology Embryo E18.5 | Syndactyly JAX | IMPC 0.00
Tmem132a
Tmem132atm1b(KOMP)Wtsi
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly BCM | IMPC 0.00
Tmem132a
Tmem132atm1b(KOMP)Wtsi
HOM E18.5 syndactyly Gross Morphology Embryo E18.5 | Syndactyly BCM | IMPC 0.00
Myo10
Myo10tm2(KOMP)Wtsi
HOM Early adult fused phalanges Combined SHIRPA and Dysmorphology | Forepaw digit fusion WTSI | IMPC 9.06×10-21
Fbn2
Fbn2em1(IMPC)Rbrc
HOM Early adult syndactyly X-ray | Syndactylism RBRC | IMPC 6.97×10-11
Smoc1
Smoc1tm1b(EUCOMM)Wtsi
HOM Early adult syndactyly X-ray | Syndactylism MRC Harwell | IMPC 3.81×10-09
Pitx1
Pitx1em1(IMPC)Wtsi
HET Early adult polysyndactyly X-ray | Polysyndactylism WTSI | IMPC 5.63×10-08
Pcdh18
Pcdh18tm1.1(KOMP)Vlcg
HOM   Early adult syndactyly X-ray | Syndactylism UC Davis | IMPC 1.13×10-06
Tcf7
Tcf7tm1a(EUCOMM)Wtsi
HOM Early adult syndactyly X-Ray | Syndactylism ICS | EuroPhenome 5.33×10-06
Gbx1
Gbx1Gbx1
HOM Early adult syndactyly X-Ray | Syndactylism ICS | EuroPhenome 1.80×10-05
Pitx1
Pitx1em1(IMPC)Wtsi
HET Early adult fused phalanges Combined SHIRPA and Dysmorphology | Hindpaw digit fusion WTSI | IMPC 4.08×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.18% of tested genes with null mutations on a B6N genetic background have a phenotype association to syndactyly (12/6665)

0.41% females (11/2677) 0.34% males (9/2678)

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