Phenotype: syndactyly

Definition
any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone
Synonyms
fused toes,  fused fingers
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with syndactyly

Total number of significant genotype-phenotype associations: 14

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Fuz
Fuzem1(IMPC)Mbp
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly UC Davis | IMPC 0.00
Snx3
Snx3tm1.1(KOMP)Vlcg
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly JAX | IMPC 0.00
Snx3
Snx3tm1.1(KOMP)Vlcg
HOM E18.5 syndactyly Gross Morphology Embryo E18.5 | Syndactyly JAX | IMPC 0.00
Tmem132a
Tmem132atm1b(KOMP)Wtsi
HOM E15.5 syndactyly Gross Morphology Embryo E14.5-E15.5 | Syndactyly BCM | IMPC 0.00
Tmem132a
Tmem132atm1b(KOMP)Wtsi
HOM E18.5 syndactyly Gross Morphology Embryo E18.5 | Syndactyly BCM | IMPC 0.00
Myo10
Myo10tm2(KOMP)Wtsi
HOM Early adult fused phalanges Combined SHIRPA and Dysmorphology | Forepaw digit fusion WTSI | IMPC 1.71×10-20
Pcdh18
Pcdh18tm1.1(KOMP)Vlcg
HOM Early adult syndactyly X-ray | Syndactylism UC Davis | IMPC 3.42×10-06
Tcf7
Tcf7tm1a(EUCOMM)Wtsi
HOM Early adult syndactyly X-Ray | Syndactylism ICS | MGP 5.33×10-06
Gbx1
Gbx1
HOM Early adult syndactyly X-Ray | Syndactylism ICS | EuroPhenome 1.80×10-05
Pitx1
Pitx1em1(IMPC)Wtsi
HET Early adult fused phalanges Combined SHIRPA and Dysmorphology | Hindpaw digit fusion WTSI | IMPC 4.88×10-05

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 The way we measure

 Phenotype associations stats

0.14% of tested genes with null mutations on a B6N genetic background have a phenotype association to syndactyly (8/5558)

0.11% females (6/5546) 0.07% males (4/5546)

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