Phenotype: abnormal aorta morphology

Definition
any structural anomaly of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal aorta morphology

Total number of significant genotype-phenotype associations: 13

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Lsm1
Lsm1tm1b(EUCOMM)Hmgu
HET Early adult abnormal aorta morphology Echo | Aortic diameter (Dao) HMGU | IMPC 0.00
Lsm1
Lsm1tm1b(EUCOMM)Hmgu
HET Early adult aorta dilation Echo | Aortic diameter (Dao) HMGU | IMPC 2.47×10-16
Cpe
Cpetm1b(EUCOMM)Hmgu
HOM Early adult abnormal aorta morphology Echo | Aortic diameter (Dao) HMGU | IMPC 5.64×10-09
Klrb1
Klrb1tm1b(EUCOMM)Wtsi
HOM Early adult aorta dilation Echo | Aortic diameter (Dao) HMGU | IMPC 1.60×10-08
Spg20
Spg20tm2b(EUCOMM)Hmgu
HOM Early adult abnormal aorta morphology Echo | Aortic diameter (Dao) HMGU | IMPC 9.06×10-08
Bmerb1
Bmerb1em1(IMPC)Ccpcz
HOM Early adult abnormal aorta morphology Echo | Aortic diameter (Dao) CCP-IMG | IMPC 6.54×10-06
Nub1
Nub1tm1b(EUCOMM)Hmgu
HOM Early adult aorta dilation Echo | Aortic diameter (Dao) CCP-IMG | IMPC 1.34×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.63% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal aorta morphology (6/368)

1.12% females (4/357) 0.84% males (3/358)



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