IMPC Gene variants with decreased circulating LDL cholesterol level
Total number of significant genotype-phenotype associations: 32
Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
---|---|---|---|---|---|---|---|
Slc29a3 Slc29a3em1(IMPC)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
1.45×10-14 | |
Brd7 Brd7tm3a(EUCOMM)Wtsi |
HET | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Fasted Clinical Chemistry |
WTSI MGP |
6.98×10-12 | |
Akap9 Akap9tm1a(KOMP)Wtsi |
HET | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
1.44×10-10 | |
Arhgap22 Arhgap22tm1a(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
7.66×10-08 | |
Prkab1 Prkab1tm1b(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
7.75×10-08 | |
Mta1 Mta1tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Fasted Clinical Chemistry |
WTSI EuroPhenome |
1.74×10-07 | |
Pex3 Pex3tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
1.97×10-07 | |
Cpgi5563 Cpgi5563tm1.1(NCC)WCS |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
2.86×10-07 | |
Sar1b Sar1btm1a(EUCOMM)Wtsi |
HET | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
2.93×10-07 | |
Sec16b Sec16btm1a(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
4.71×10-07 | |
Setd1a Setd1atm1a(EUCOMM)Wtsi |
HET | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
8.49×10-07 | |
Ube3b Ube3bGt(RRJ142)Byg |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
2.06×10-06 | |
Tex261 Tex261tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
5.33×10-06 | |
Spns2 Spns2tm1a(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI EuroPhenome |
8.86×10-06 | |
Sqstm1 Sqstm1tm1a(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
1.11×10-05 | |
Elk4 Elk4tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Fasted Clinical Chemistry |
HMGU EuroPhenome |
1.13×10-05 | |
Sesn3 Sesn3tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
1.16×10-05 | |
Sidt2 Sidt2em1(IMPC)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
2.19×10-05 | |
Wdtc1 Wdtc1tm1a(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
2.62×10-05 | |
Sec24a Sec24atm1a(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
3.23×10-05 | |
Mysm1 Mysm1tm1a(KOMP)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI EuroPhenome |
3.76×10-05 | |
Fbf1 Fbf1tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
3.87×10-05 | |
Wdr47 Wdr47tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI EuroPhenome |
4.31×10-05 | |
Dscc1 Dscc1tm1a(KOMP)Wtsi |
HET | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
4.44×10-05 | |
Dlg2 Dlg2tm1Dsb |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI EuroPhenome |
5.36×10-05 | |
Wrap53 Wrap53tm1b(EUCOMM)Wtsi |
HET | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI IMPC |
6.77×10-05 | |
Anxa6 Anxa6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI MGP |
6.90×10-05 | |
Hells Hellstm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Fasted Clinical Chemistry |
HMGU EuroPhenome |
7.52×10-05 | |
Aldh2 Aldh2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased circulating LDL cholesterol level | LDL-cholesterol Clinical Chemistry |
WTSI EuroPhenome |
7.67×10-05 |