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Phenotype: increased circulating LDL cholesterol level

Definition
greater amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions
Synonyms
elevated circulating LDL cholesterol level
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased circulating LDL cholesterol level

Total number of significant genotype-phenotype associations: 49

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Ap2a2
Ap2a2tm1b(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 0.00
Apoe
Apoetm1Unc 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 0.00
D6Wsu163e
D6Wsu163etm1b(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.36×10-12
Tchp
Tchptm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.35×10-11
Reg3g
Reg3gtm1a(KOMP)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.35×10-10
Usp33
Usp33tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 9.66×10-09
Gm20646
Gm20646em1(IMPC)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.51×10-08
Smyd2
Smyd2tm1a(KOMP)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Fasted Clinical Chemistry		 WTSI
EuroPhenome		 1.62×10-08
Ct45a
Ct45atm1e(KOMP)Wtsi 		HEM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.82×10-08
Ccdc77
Ccdc77tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.87×10-08
Ap2a2
Ap2a2em1(IMPC)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.80×10-08
Stk32a
Stk32atm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 7.80×10-08
Ehmt1
Ehmt1tm1b(EUCOMM)Hmgu 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.82×10-08
Ak4
Ak4em1(IMPC)Kmpc 		HOM Late adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 KMPC
IMPC		 8.69×10-08
Nfkb1
Nfkb1tm1a(KOMP)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Fasted Clinical Chemistry		 WTSI
EuroPhenome		 1.45×10-07
Hdac3
Hdac3tm1a(EUCOMM)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 2.37×10-07
Ttll4
Ttll4tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 3.24×10-07
Ago1
Ago1tm1a(KOMP)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 5.14×10-07
Usp11
Usp11tm1(KOMP)Wtsi 		HEM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.11×10-06
Dars2
Dars2tm1a(KOMP)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.12×10-06
Glra4
Glra4tm1b(KOMP)Wtsi 		HEM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.26×10-06
Appl2
Appl2tm1a(KOMP)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.36×10-06
Flvcr2
Flvcr2tm1a(EUCOMM)Hmgu 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.39×10-06
Col6a3
Col6a3em1(IMPC)Kmpc 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 KMPC
IMPC		 5.25×10-06
Ift25
Ift25tm1a(EUCOMM)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Fasted Clinical Chemistry		 WTSI
EuroPhenome		 6.21×10-06
Mbtd1
Mbtd1tm2a(EUCOMM)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 6.96×10-06
Snx8
Snx8tm2a(EUCOMM)Hmgu 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.05×10-06
Prkcz
Prkcztm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 7.07×10-06
Fgd4
Fgd4tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.12×10-05
Pdzk1
Pdzk1tm2b(EUCOMM)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.13×10-05
Irgm1
Irgm1em1(IMPC)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.15×10-05
Tm9sf4
Tm9sf4tm1a(KOMP)Wtsi 		HOM   Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.19×10-05
Csnk1g3
Csnk1g3tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.30×10-05
Kif13b
Kif13btm1b(EUCOMM)Wtsi 		HOM   Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.33×10-05
Phf8
Phf8em2(IMPC)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.46×10-05
Oxtr
Oxtrtm1.1(KOMP)Vlcg 		HOM   Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 RBRC
IMPC		 1.70×10-05
Tecr
Tecrem1(IMPC)Rbrc 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 RBRC
IMPC		 3.80×10-05
Nr0b1
Nr0b1em2(IMPC)Wtsi 		HEM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 4.20×10-05
Cdca8
Cdca8tm1a(KOMP)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.30×10-05
Ehd1
Ehd1tm1a(EUCOMM)Wtsi 		HET Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 6.13×10-05
Prdx6
Prdx6tm1a(EUCOMM)Wtsi 		HOM Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 6.94×10-05
Cav3
Cav3em1(IMPC)Kmpc 		HOM   Early adult increased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 KMPC
IMPC		 8.66×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Fasted Clinical Chemistry
Terminal Bleed

 Phenotype associations stats

2.47% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating LDL cholesterol level (42/1702)

0.94% females (16/1706) 1.70% males (29/1705)

Select a parameter    



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