Gross Pathology and Tissue Collection: Images
WT Images
59 weeks old
Comments (in English): The mouse was obese. There was hair loss on dorsal side along neck and back.
Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - abnormal salivary gland morphology, diameter=2.5, brown lesion; skin - abnormal skin morphology, area=6x4, embedded in subcutaneous fat of right inguinal area; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view fat attached to xiphoid process of sternum
59 weeks old
Comments (in English): There were hairless patches around both eyes extended to base of ear. Patch sizes were 20x8mm for right side and 10x6mm for left side. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Laternal view of hairless patched around eyes; hairless patches around eyes,
Comments (in English): Internal view
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Both kidneys were surrounded by adipose tissue,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Comments (in English): Animal was obese with hair loss on neck and back.
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - small kidney, area=8x5, embedded in fat; lung - small lung, compressed by abundant fat in thoracic cavity,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of sternum; diameter=4
59 weeks old
Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Rule out hemorrhage, twisiting of root blood vessels,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of left ovary; swollen; area=5x4
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries; with brown and white nodules
59 weeks old
Liver: PATO:0000627,
Liver: PATO:0000322,
Liver: PATO:0001323,
Liver: PATO:0000407,
Liver: MP:0000598,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): reproductive gland; Internal view of enlarged preputial gland; enlarged, red and yellow; area=10x18
59 weeks old
Comments (in English): The mouse was obese with grey hair interpersed with black hair. Animal was bright, alert and responsive wit normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of white nodule and white fat on sternum; nodule on inner side of sternum; area=4x3
59 weeks old
Comments (in English): Yellow fluid kept coming out of penis. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=11x7, right inguinal region,
Comments (in English): Lateral view,
Comments (in English): ankle; Lateral view of ankles that won't extend straight; both ankles won't extend straight,
Comments (in English): Internal view
59 weeks old
Comments (in English): The mouse was obese. There was hair loss on dorsal side along neck and back.
Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - abnormal salivary gland morphology, diameter=2.5, brown lesion; skin - abnormal skin morphology, area=6x4, embedded in subcutaneous fat of right inguinal area; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view fat attached to xiphoid process of sternum,
Sternum: MP:0002169
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend.
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries; with brown and white nodules
59 weeks old
Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2
59 weeks old
Comments (in English): The mouse was obese with grey hair interpersed with black hair. Animal was bright, alert and responsive wit normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of white nodule and white fat on sternum; nodule on inner side of sternum; area=4x3,
Sternum: PATO:0001323,
Sternum: PATO:0000323,
Sternum: PATO:0000386,
Sternum: MP:0000157
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): reproductive gland; Internal view of enlarged preputial gland; enlarged, red and yellow; area=10x18
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Rule out hemorrhage, twisiting of root blood vessels,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of left ovary; swollen; area=5x4
59 weeks old
Liver: PATO:0000627,
Liver: PATO:0000322,
Liver: PATO:0001323,
Liver: PATO:0000407,
Liver: MP:0000598,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2
59 weeks old
Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend.
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding
59 weeks old
Comments (in English): The mouse was obese with grey hair interpersed with black hair. Animal was bright, alert and responsive wit normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of white nodule and white fat on sternum; nodule on inner side of sternum; area=4x3
59 weeks old
Ovary: PATO:0000329,
Ovary: MP:0001126,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries; with brown and white nodules
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): reproductive gland; Internal view of enlarged preputial gland; enlarged, red and yellow; area=10x18
59 weeks old
Comments (in English): There were hairless patches around both eyes extended to base of ear. Patch sizes were 20x8mm for right side and 10x6mm for left side. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Laternal view of hairless patched around eyes; hairless patches around eyes,
Comments (in English): Internal view
59 weeks old
Ovary: PATO:0000366,
Ovary: MP:0001126,
Ovary: PATO:0000322,
Ovary: PATO:0001323,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Rule out hemorrhage, twisiting of root blood vessels,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of left ovary; swollen; area=5x4
59 weeks old
Comments (in English): Animal was obese with hair loss on neck and back.
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - small kidney, area=8x5, embedded in fat; lung - small lung, compressed by abundant fat in thoracic cavity,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of sternum; diameter=4,
Sternum: PATO:0000627,
Sternum: PATO:0001334,
Sternum: MP:0000157
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2
59 weeks old
Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend.
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding
59 weeks old
Seminal vesicle: PATO:0001323,
Seminal vesicle: MP:0002059,
Seminal vesicle: PATO:0000322,
Seminal vesicle: PATO:0000366,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2
59 weeks old
Skin: PATO:0000627,
Skin: MP:0002060,
Comments (in English): There were hairless patches around both eyes extended to base of ear. Patch sizes were 20x8mm for right side and 10x6mm for left side. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Laternal view of hairless patched around eyes; hairless patches around eyes,
Comments (in English): Internal view
59 weeks old
Comments (in English): Yellow fluid kept coming out of penis. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=11x7, right inguinal region,
Comments (in English): Lateral view,
Comments (in English): ankle; Lateral view of ankles that won't extend straight; both ankles won't extend straight,
Comments (in English): Internal view
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of lesion on right medium lobe; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view of lesion on right medium lobe; lesion on right median lobe surrounded by darkerred colour; area=4x2,
Comments (in English): seminal vesicles; Internal view of red left seminal vesicle; image I3; area=12x3,
Comments (in English): liver; Internal view; mass attached to caudate lobe; area=15x12,
Comments (in English): liver; Internal view; lesion on right median lobe surrounded by darkerred colour; area=4x2
59 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Both kidneys were surrounded by adipose tissue,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Comments (in English): Yellow fluid kept coming out of penis. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=11x7, right inguinal region,
Comments (in English): Lateral view,
Comments (in English): ankle; Lateral view of ankles that won't extend straight; both ankles won't extend straight,
Comments (in English): Internal view
59 weeks old
Lymph node: MP:0000702,
Lymph node: PATO:0001323,
Lymph node: PATO:0000627,
Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2
59 weeks old
Ovary: MP:0001126,
Ovary: PATO:0000952,
Comments (in English): The mouse was obese. There was small area (5x7mm) of alopecia around left eye. Animal was bright, alert and responsive with and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ovary; Internal view of ovaries,
Comments (in English): lymph nodes; Internal (dorsal) view og enlarged lymph node in salivary region; in salivary region; area=3x2
59 weeks old
Comments (in English): Animal was obese
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - normal, embedded in fat; spleen - small spleen, area=15x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): testis; Internal view of testes; right:8x6mm; area=5x3
59 weeks old
Comments (in English): The mouse was obese. There was hair loss on dorsal side along neck and back.
Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - abnormal salivary gland morphology, diameter=2.5, brown lesion; skin - abnormal skin morphology, area=6x4, embedded in subcutaneous fat of right inguinal area; uterus - thin uterus, diameter=1,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view fat attached to xiphoid process of sternum
59 weeks old
Comments (in English): Animal was obese
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - normal, embedded in fat; spleen - small spleen, area=15x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): testis; Internal view of testes; right:8x6mm; area=5x3
59 weeks old
Comments (in English): Animal had rough furcoat. There were some healed scabs in between scapulae. Left ankle was unable to extend.
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - abnormal liver morphology, pale red or brown; skin - abnormal skin morphology, scabs in between scapulae,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): ankle; Internal view of left ankle unable to extend; unable to extend,
Comments (in English): sternum; Internal view of protruding xiphoid process; xiphoid process protruding,
Sternum: MP:0000157
59 weeks old
Comments (in English): Animal was obese with hair loss on neck and back.
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - small kidney, area=8x5, embedded in fat; lung - small lung, compressed by abundant fat in thoracic cavity,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): sternum; Internal view of sternum; diameter=4
59 weeks old
Testes: PATO:0000366,
Testes: PATO:0001323,
Testes: PATO:0000952,
Testes: MP:0001147,
Comments (in English): Animal was obese
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; kidney - normal, embedded in fat; spleen - small spleen, area=15x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): testis; Internal view of testes; right:8x6mm; area=5x3
Mutant Images
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Grey hairs interpersed with blabk ones.
Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lymph nodes - enlarged lymph nodes, mesentary; seminal vesicles - abnormal seminal vesicle morphology, enlarged; spleen - small spleen, area=14x3,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): salivary gland; Internal view of lesions on salivary gland; 5 lesion, lymph nodes?; area=5x3
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.
Several white nodules on bilateral aspects of salivary glands (about 1x1mm in size each). Total area of nodules 6x3mm on left side and 2x2mm on right side.; salivary gland - abnormal salivary gland morphology, multiple nodules on lateral (1x1mm) aspects of gland, 6x3mm on left and 2x2mm on right; kidney - abnormal kidney morphology, both kidneys and ad...,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): Internal view of multiple lesions around salivary gland
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - enlarged salivary gland, area=25x10; kidney - normal, embedded in fat; liver - normal, pale,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.
Several white nodules on bilateral aspects of salivary glands (about 1x1mm in size each). Total area of nodules 6x3mm on left side and 2x2mm on right side.; salivary gland - abnormal salivary gland morphology, multiple nodules on lateral (1x1mm) aspects of gland, 6x3mm on left and 2x2mm on right; kidney - abnormal kidney morphology, both kidneys and ad...,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): Internal view of multiple lesions around salivary gland
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Grey hairs interpersed with blabk ones.
Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lymph nodes - enlarged lymph nodes, mesentary; seminal vesicles - abnormal seminal vesicle morphology, enlarged; spleen - small spleen, area=14x3,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): salivary gland; Internal view of lesions on salivary gland; 5 lesion, lymph nodes?; area=5x3,
Salivary gland: PATO:0001323,
Salivary gland: MP:0000613,
Salivary gland: PATO:0001791,
Salivary gland: PATO:0000322
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; salivary gland - enlarged salivary gland, area=25x10; kidney - normal, embedded in fat; liver - normal, pale,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Grey hairs interpersed with blabk ones.
Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lymph nodes - enlarged lymph nodes, mesentary; seminal vesicles - abnormal seminal vesicle morphology, enlarged; spleen - small spleen, area=14x3,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): salivary gland; Internal view of lesions on salivary gland; 5 lesion, lymph nodes?; area=5x3
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; heart - abnormal heart morphology, abundant fat in thoracic cavity and around heart; kidney - abnormal kidney morphology, both kidneys and adrenals embedded in significant fat; lymph nodes - enlarged lymph nodes, area=10x5, enlarged LN in mesentary; skin - abnormal skin morphology, abundant sub cutaneous fat,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; heart - abnormal heart morphology, abundant fat in thoracic cavity and around heart; kidney - abnormal kidney morphology, both kidneys and adrenals embedded in significant fat; lymph nodes - enlarged lymph nodes, area=10x5, enlarged LN in mesentary; skin - abnormal skin morphology, abundant sub cutaneous fat,
Comments (in English): Lateral view,
Comments (in English): Internal view
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.
Several white nodules on bilateral aspects of salivary glands (about 1x1mm in size each). Total area of nodules 6x3mm on left side and 2x2mm on right side.; salivary gland - abnormal salivary gland morphology, multiple nodules on lateral (1x1mm) aspects of gland, 6x3mm on left and 2x2mm on right; kidney - abnormal kidney morphology, both kidneys and ad...,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): Internal view of multiple lesions around salivary gland
59 weeks old
Phrf1em1(IMPC)Tcp homozygote
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; heart - abnormal heart morphology, abundant fat in thoracic cavity and around heart; kidney - abnormal kidney morphology, both kidneys and adrenals embedded in significant fat; lymph nodes - enlarged lymph nodes, area=10x5, enlarged LN in mesentary; skin - abnormal skin morphology, abundant sub cutaneous fat,
Comments (in English): Lateral view,
Comments (in English): Internal view
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