Eye Morphology: Images Ophthalmoscopy

WT Images

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: LEFT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia ; LEFT EYE: A little bit of Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia; LEFT EYE: Slight opacity on lens, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Severe Rd8; LEFT EYE: Slight lens opacity, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

Mutant Images

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Blood vessels branch early and crosses,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; LEFT EYE: Slight corneal opacity, difficult to focus and image.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; LEFT EYE: Some corneal opacity. Slight haemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; RIGHT EYE: Some rd8, maybe a small lesion present,
Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; LEFT EYE: Slight corneal opacity, difficult to focus and image.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Blood vessels branch early and crosses,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8; LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; RIGHT EYE: Some rd8, maybe a small lesion present,
Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia; LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; RIGHT EYE: A lesion present,
Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; LEFT EYE: Some corneal opacity. Slight haemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; LEFT EYE: Some corneal opacity. Slight haemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; RIGHT EYE: Some rd8, maybe a small lesion present,
Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; RIGHT EYE: Some depigmentation close to optic nerve. Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage ; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Blood vessels branch early and crosses,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; LEFT EYE: Slight corneal opacity, difficult to focus and image.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; RIGHT EYE: Some rd8, maybe a small lesion present,
Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage ; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; RIGHT EYE: A lesion present,
Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage ; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; LEFT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; LEFT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; RIGHT EYE: A lesion present,
Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; LEFT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage ; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; RIGHT EYE: Some depigmentation close to optic nerve. Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8; LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; LEFT EYE: Slight corneal opacity, difficult to focus and image.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; RIGHT EYE: A lesion present,
Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia; LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Blood vessels branch early and crosses,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; LEFT EYE: Slight corneal opacity, difficult to focus and image.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; LEFT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia; LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).Restless mouse (difficult to image).; RIGHT EYE: Severe rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; LEFT EYE: Some corneal opacity. Slight haemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight haemorrhaging.; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; RIGHT EYE: Some depigmentation close to optic nerve. Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; LEFT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; LEFT EYE: Some corneal opacity. Slight haemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; RIGHT EYE: A lesion present,
Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; RIGHT EYE: Some depigmentation close to optic nerve. Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia; LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; LEFT EYE: Slight corneal opacity, difficult to focus and image.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8 and dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia; LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8; LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Restless mouse. Both eyes severe rd8, moderate dysplasia; RIGHT EYE: Slight lens opacity

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia; LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; RIGHT EYE: Some rd8, maybe a small lesion present,
Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some dysplasia; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight haemorrhaging; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes severe dysplasia. Restless mouse (difficult to image). Slight lens opacity.; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia; LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity, severe dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, cataracts formation/crystallized debris, moderate dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8; LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; LEFT EYE: Cataract formation,
Ophthalmoscope Observation: Both eyes some lens opacity, moderate dysplasia, some rd8 ; RIGHT EYE: Cotton patches debris

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; RIGHT EYE: Some depigmentation close to optic nerve. Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; LEFT EYE: Some corneal opacity. Slight haemorrhaging,
Ophthalmoscope Observation: Both eyes some lens opacity. Slight dysplasia ; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; RIGHT EYE: Some rd8, maybe a small lesion present,
Ophthalmoscope Observation: Both eyes corneal opacity, difficult to focus and image. Some dysplasia; LEFT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; LEFT EYE: Slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity and debris (difficult to focus).; RIGHT EYE: Hyaloid present.Slight dysplasia. Slight hemorrhaging.

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Blood vessels branch early and crosses,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Lesion below optic nerve,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some dysplasia

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some lens opacity, some dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage ; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; RIGHT EYE:

58 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; RIGHT EYE: A lesion present,
Ophthalmoscope Observation: Both eyes some lens opacity, difficult to focus and image. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity and some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; RIGHT EYE: Some depigmentation close to optic nerve. Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity. Some rd8; LEFT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; LEFT EYE: Blood vessels branch early and crosses,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight corneal opacity and slight lens opacity (difficult to focus), some rd8, some dysplasia; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8; LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage ; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity difficult to focus and image,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus and image, slight hemorrhage

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; LEFT EYE: Some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, moderate dysplasia ; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity difficult to focus and image, some rd8, slight hemorrhaging; RIGHT EYE:

57 weeks old

Adamtsl3em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8; LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity (difficult to focus), severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, moderate rd8

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