Eye Morphology: Images Ophthalmoscopy

WT Images

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: LEFT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia ; LEFT EYE: A little bit of Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia; LEFT EYE: Slight opacity on lens, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Severe Rd8; LEFT EYE: Slight lens opacity, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

Mutant Images

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE: Some dysplasia

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE: Some dysplasia

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage ; RIGHT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight hemorrhage ; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: slight lens opacity,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8 and slight lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8 and slight lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8; RIGHT EYE: slight dysplasia,
Ophthalmoscope Observation: Both eyes slight rd8; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid presetn and some rd8,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus; LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid presetn and some rd8,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8; RIGHT EYE: slight dysplasia,
Ophthalmoscope Observation: Both eyes slight rd8; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: slight lens opacity,
Ophthalmoscope Observation: LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: slight lens opacity,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE: Some dysplasia

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8; RIGHT EYE: slight dysplasia,
Ophthalmoscope Observation: Both eyes slight rd8; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8, Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage ; RIGHT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight hemorrhage ; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: slight lens opacity,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus; LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8, Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hard to focus (some opacity),
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); LEFT EYE:,
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8, Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage ; RIGHT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight hemorrhage ; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8; RIGHT EYE: slight dysplasia,
Ophthalmoscope Observation: Both eyes slight rd8; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8, Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage ; RIGHT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight hemorrhage ; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8 and slight lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid presetn and some rd8,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus; LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: slight lens opacity,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus; LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage ; RIGHT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight hemorrhage ; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE: Some dysplasia

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8 and slight lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hard to focus (some opacity),
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); LEFT EYE:,
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hard to focus (some opacity),
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); LEFT EYE:,
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8, Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: slight lens opacity,
Ophthalmoscope Observation: LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8; RIGHT EYE: slight dysplasia,
Ophthalmoscope Observation: Both eyes slight rd8; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8 and slight lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hard to focus (some opacity),
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); LEFT EYE:,
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid presetn and some rd8,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE: Some dysplasia

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hard to focus (some opacity),
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); LEFT EYE:,
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity/debris ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid presetn and some rd8,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8; RIGHT EYE: slight dysplasia,
Ophthalmoscope Observation: Both eyes slight rd8; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; LEFT EYE: Slight lens opacity.,
Ophthalmoscope Observation: Both eyes some rd8.; RIGHT EYE: Moderate lens opacity (very difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid presetn and some rd8,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid presetn and some rd8,
Ophthalmoscope Observation: LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage ; RIGHT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight hemorrhage ; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE: Some dysplasia

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus; LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and moderate lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus; LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: LEFT EYE: Small lesion, and some dysplasia,
Ophthalmoscope Observation: RIGHT EYE: Lens opacity, difficult to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: LEFT EYE: Hyaloid present and moderate rd8. Some lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8 and slight lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Hyaloid present and some rd8. Moderate lens opacity ( difficult to image and focus).

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage ; RIGHT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight hemorrhage ; LEFT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hard to focus (some opacity),
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); LEFT EYE:,
Ophthalmoscope Observation: Both eyes hard to focus (some opacity); RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE: Hyaloid present and some dysplasia.,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Hyaloid present .

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes moderate rd8 ; RIGHT EYE: Moderate rd8

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: LEFT EYE: Severe rd8. Some odd vessel branching and lens opacity (difficult to focus).,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8 and opacity on lens

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity ( difficult to focus).; RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity ( difficult to image and focus).; LEFT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Restless/rapid breathing mouse (difficult to image).; RIGHT EYE: Some rd8 and slight lens opacity.

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: White crystalline stuff in vitreous, slight opacity on lens, hard to focus

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: LEFT EYE: Some rd8, Slight lens opacity,
Ophthalmoscope Observation: RIGHT EYE:

58 weeks old

Rnf135em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Slight rd8; LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Slight rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight rd8

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