Eye Morphology: Images Ophthalmoscopy

WT Images

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: LEFT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia ; LEFT EYE: A little bit of Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia; LEFT EYE: Slight opacity on lens, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Severe Rd8; LEFT EYE: Slight lens opacity, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

Mutant Images

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Some dysplasia and slight hemorrhaging.,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia ; LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia ; LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; LEFT EYE: slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia ; LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; RIGHT EYE: Blood vessel crossing slightly,
Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; LEFT EYE:,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some dysplasia.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; RIGHT EYE: Blood vessel crossing slightly,
Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; LEFT EYE:,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Some dysplasia and slight hemorrhaging.,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Some dysplasia and slight hemorrhaging.,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; RIGHT EYE: Blood vessel crossing slightly,
Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some dysplasia.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; LEFT EYE:,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some dysplasia.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; LEFT EYE: slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; RIGHT EYE: Blood vessel crossing slightly,
Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; LEFT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia ; LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; LEFT EYE: slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some dysplasia.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; LEFT EYE:,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes severe rd8; RIGHT EYE: Thick lens opacity difficult to focus and obstructing the retina

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; LEFT EYE: slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Some dysplasia and slight hemorrhaging.,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; RIGHT EYE: Blood vessel crossing slightly,
Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some dysplasia.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; LEFT EYE: slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; LEFT EYE: Slight lens opacity, some dysplasia,
Ophthalmoscope Observation: Both eyes hyaloid present ; RIGHT EYE: Bright patches on lens, some lens opacity, difficult to focus and image, some small lesions

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia ; LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; LEFT EYE: Some dysplasia.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to image and focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; LEFT EYE:,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; LEFT EYE:,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and some lens opacity ; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Some dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: LEFT EYE: Some rd8, hard to focus,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; LEFT EYE:,
Ophthalmoscope Observation: Cataract/lens opacity - some retinal obstruction. Both eyes moderate rd8.; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage ; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Slight lens opacity, and crystallized debris. Abnormal blood vessel branching and crossing. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Some hemorrhage

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Some dysplasia and slight hemorrhaging.,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE:

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Some rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; LEFT EYE: Some dysplasia and slight hemorrhaging.,
Ophthalmoscope Observation: Both eyes slight lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some rd8 and slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Opaque cotton patches on lens or in vitreous, retina appears normal but difficult to image and focus.

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus ; RIGHT EYE: Some rd8, slight hemorrhage

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8,slight hemorrhage ; RIGHT EYE: Some lens opacity difficult to focus

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; RIGHT EYE: Blood vessel crossing slightly,
Ophthalmoscope Observation: Both eyes severe rd8, some lens opacity ; LEFT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and slight lens opacicty.; RIGHT EYE: Severe rd8

58 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Severe rd8, blood vessel abnormal branching,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Hyaloid present, moderate rd8

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity (hard to focus), slight rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia ; LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Some lens opacity difficult to focus, some rd8, some hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Slight lens opacity, small lesion, some dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; LEFT EYE: Slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight dysplasia; RIGHT EYE: Slight dysplasia

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; LEFT EYE: slight lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia rd8; RIGHT EYE:

57 weeks old

Cdk12em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; LEFT EYE: Some lens opacity difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, some hemorrhage ; RIGHT EYE: Slight dysplasia, slight lens opacity

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