Gross Pathology and Tissue Collection: Images
WT Images
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
15 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view
16 weeks old
16 weeks old
16 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view
16 weeks old
16 weeks old
16 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view
16 weeks old
16 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view
15 weeks old
16 weeks old
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
16 weeks old
Mutant Images
16 weeks old
Lbrem1(IMPC)Tcp homozygote
Comments (in English): sparse and short hair all over the body
multiple nodules on tail
fused toe---digit 2 and 3 fused on hind paws and front paws; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Forelimbs and hindlimbs interdigital webbing,
Comments (in English): hand digit; fused 2nd and 3rd digits on right hand,
Comments (in English): foot digit; fused 2nd and 3rd digits on right foot
16 weeks old
Lbrem1(IMPC)Tcp homozygote
16 weeks old
Lbrem1(IMPC)Tcp homozygote
16 weeks old
Lbrem1(IMPC)Tcp homozygote
16 weeks old
Lbrem1(IMPC)Tcp homozygote
Comments (in English): Smaller than WT littermate
Sparse hair, especially hair on dorsal skin
Rigid tail with rough tail skin and multiple nodules
Soft tissues between 2nd and 3rd digits of the front paws fused
Sticky and translucent secretion at the anal opening; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Forelimbs interdigital webbing,
Comments (in English): hand; 2nd and 3rd digits fused
16 weeks old
Lbrem1(IMPC)Tcp homozygote
Comments (in English): Smaller than its WT littermate of the same sex.
Short and sparse hairs on upper body and almost no hairs on lower back.
Soft tissues between 2nd and 3rd digits of the front paws fused
Rigid tail and rough tail skin with multiple nodules
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lymph nodes - enlarged lymph nodes, area=4x3, salivary region; lymph nodes - enlarged lymph nodes, area=3x2, inguinal; seminal vesicles - small seminal vesicle, area=17x4; testis - small testis, a...,
Comments (in English): hand; 2nd and 3rd digits fused,
Comments (in English): hand; 2nd and 3rd digits fused (after fixation)
16 weeks old
Lbrem1(IMPC)Tcp homozygote
16 weeks old
Lbrem1(IMPC)Tcp homozygote
16 weeks old
Lbrem1(IMPC)Tcp homozygote
16 weeks old
Lbrem1(IMPC)Tcp homozygote
Comments (in English): Smaller than its WT littermate of the same sex.
Short and sparse hairs on upper body and almost no hairs on lower back.
Soft tissues between 2nd and 3rd digits of the front paws fused
Rigid tail and rough tail skin with multiple nodules
There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lymph nodes - enlarged lymph nodes, area=4x3, salivary region; lymph nodes - enlarged lymph nodes, area=3x2, inguinal; seminal vesicles - small seminal vesicle, area=17x4; testis - small testis, a...,
Comments (in English): hand; 2nd and 3rd digits fused,
Comments (in English): hand; 2nd and 3rd digits fused (after fixation)
16 weeks old
Lbrem1(IMPC)Tcp homozygote
16 weeks old
Lbrem1(IMPC)Tcp homozygote
Comments (in English): sparse and short hair all over the body
multiple nodules on tail
fused toe---digit 2 and 3 fused on hind paws and front paws; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; Pathologist's comments: Forelimbs and hindlimbs interdigital webbing,
Comments (in English): hand digit; fused 2nd and 3rd digits on right hand,
Comments (in English): foot digit; fused 2nd and 3rd digits on right foot
16 weeks old
Lbrem1(IMPC)Tcp homozygote
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