Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; LEFT EYE: Early vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; LEFT EYE: Early vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; LEFT EYE: Tiny hyaloid present. Blood vessel crossing and slightly early branching. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina); LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina)

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; LEFT EYE: Early vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia ; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina); LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina)

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; LEFT EYE: Tiny hyaloid present. Blood vessel crossing and slightly early branching. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; LEFT EYE: Tiny hyaloid present. Blood vessel crossing and slightly early branching. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia ; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; LEFT EYE: Early vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia ; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; LEFT EYE: Tiny hyaloid present. Blood vessel crossing and slightly early branching. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, small lesions; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia ; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina); LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina)

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia ; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia ; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina); LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina)

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; LEFT EYE: Early vessel branching and slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 and slight hemorrhaging ; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, multiple hyaloid present, blood vessel early branching

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; LEFT EYE: Early vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; LEFT EYE: Tiny hyaloid present. Blood vessel crossing and slightly early branching. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina); LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina)

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes small crystallized debris, some rd8 ; RIGHT EYE: Multiple Hyaloid present, early blood vessel branching, very slight lens opacity

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina); LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Bright multiple crystallized debris (obstructing part of the retina)

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia ; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Crystallized debris present (difficult to focus),
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Tiny hyaloid present. Slight dysplasia

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Very slight lens opacity. Bright crystallized debris obstructing part of the retina. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity. Crystallized debris. Hyaloid present obstructing the optic nerve

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; LEFT EYE: Slight corneal opacity, bright crystallized debris (obstructing the retina),
Ophthalmoscope Observation: Both eyes hyaloid present, some lens opacity opacity (difficult to focus), some rd8, slight hemorrhage ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; LEFT EYE: Some lens opacity (difficult to focus). Early vessel branching.,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging; RIGHT EYE: Slight lens opacity

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris present. Some rd8; RIGHT EYE: Slight dysplasia, slight hemorrhage

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; LEFT EYE: Early vessel branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and lens opacity.; RIGHT EYE:

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; LEFT EYE: Tiny hyaloid present. Blood vessel crossing and slightly early branching. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; RIGHT EYE:

14 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; LEFT EYE: Slight lens opacity. Blood vessel crossing,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, blood vessel early branching; RIGHT EYE: Very slight lens opacity, crystallized debris, slight hemorrhage

15 weeks old

Ddx46em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; LEFT EYE: Tiny hyaloid present. Blood vessel crossing and slightly early branching. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus). Some rd8, slight dysplasia ; RIGHT EYE:

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