Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; RIGHT EYE: Crystallized debris, bright speck, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; RIGHT EYE: Blood vessel crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; LEFT EYE: Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Multiple tiny hyaloid, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Multiple tiny hyaloid, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching; LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Multiple tiny hyaloid, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; LEFT EYE: Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; LEFT EYE: Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; LEFT EYE: Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; RIGHT EYE: Blood vessel crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Multiple tiny hyaloid, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; RIGHT EYE: Crystallized debris, bright speck, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; LEFT EYE: Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; RIGHT EYE: Crystallized debris, bright speck, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; RIGHT EYE: Crystallized debris, bright speck, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; RIGHT EYE: Blood vessel crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching; LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; LEFT EYE: Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, small crystallized debris, some rd8; RIGHT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching; LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; RIGHT EYE: Crystallized debris, bright speck, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; RIGHT EYE: Blood vessel crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching; LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching; LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Multiple tiny hyaloid, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Multiple tiny hyaloid, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; LEFT EYE: Very slight lens opacity, multiple tiny hyaloid present, some rd8,,
Ophthalmoscope Observation: Both eyes slight hemorrhage; RIGHT EYE: Slight lens opacity, slight rd8, slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; RIGHT EYE: Multiple tiny hyaloid, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage ; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris ; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, multiple tiny hyaloid, slight rd8, very slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; RIGHT EYE: Blood vessel crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; RIGHT EYE: Blood vessel crossing, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel slightly early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching; LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, moderate rd8, slight dysplasia, blood vessel early branching,
Ophthalmoscope Observation: RIGHT EYE: Very slight lens opacity, some rd8, slight hemorrhage, blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; RIGHT EYE: Crystallized debris, bright speck, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; LEFT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight dysplasia, some rd8, slight hemorrhage ; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Crystallized debris, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Hyaloid present.,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Multiple tiny hyaloids. Blood vessel slightly early branching

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; LEFT EYE: Slight rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity; RIGHT EYE: Crystallized debris present. Some rd8, some dysplasia, slight hemorrhage

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; RIGHT EYE: Difficult to focus,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp hemizygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; RIGHT EYE: Crystallized debris, bright speck, small hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, blood vessel early branching and crossing; LEFT EYE:

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, blood vessel early branching, some rd8, slight dysplasia; RIGHT EYE: Hyaloid present

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Slight hemorrhage, small lesion,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel early branching and crossing

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

14 weeks old

Rnf113a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Slight corneal opacity, slight lens opacity. Massive hyaloid present (obstructing the optic nerve and retina, difficult to focus and image),
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Very slight lens opacity, bright patches (obstructing part of retina). Blood vessel early branching. Slight dysplasia

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