Gross Pathology and Tissue Collection: Images

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

15 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

15 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Eye with optic nerve: MP:0001293,
Eye with optic nerve: PATO:0000367,
Comments (in English): Right eye was closed and left eye was small. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): eye; Internal view of eyeballs; small left eyeball; 1.5mm in diameter

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): The mouse had thining fur on thorax with area of 30x16mm. Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; eye - abnormal eye morphology, cloudy; spleen - enlarged spleen, area=21x6; sternum - abnormal sternum morphology, xiphoid process protrudes 3mm,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough and lobulated liver; rough and very lobulated,
Comments (in English): skin; Lateral view of thining hair on thorax

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with rough furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - enlarged spleen, area=17x7; testes - small testis, area=6.5x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of liver; rough surface with rounded edges, multiple nodules; diameters of nodules 3mm to 5mm

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - normal, black region (4x4mm) on cranial-dorsal end,
Comments (in English): Lateral view,
Comments (in English): Internal view

17 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Liver: MP:0000598,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - enlarged spleen, area=14x7,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough surface of liver; rough surface with multiple nodules,
Comments (in English): liver; Internal view of rough surface of liver with multiple nodules; rough surface with multiple nodules

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lymph nodes - enlarged lymph nodes, area=L:4x2, R:4.5x2.5, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

17 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - enlarged spleen, area=14x7,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough surface of liver; rough surface with multiple nodules,
Comments (in English): liver; Internal view of rough surface of liver with multiple nodules; rough surface with multiple nodules

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; eye - abnormal eye morphology, right eye sunken further into skull (could not bleed from it); spleen - enlarged spleen, area=20x7,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of liver; rough and lobulated

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Liver: MP:0000598,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; eye - abnormal eye morphology, right eye sunken further into skull (could not bleed from it); spleen - enlarged spleen, area=20x7,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of liver; rough and lobulated

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Right eye was closed and left eye was small. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): eye; Internal view of eyeballs; small left eyeball; 1.5mm in diameter

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with rough furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - enlarged spleen, area=17x7; testes - small testis, area=6.5x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of liver; rough surface with rounded edges, multiple nodules; diameters of nodules 3mm to 5mm

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Liver: MP:0000598,
Comments (in English): Animal was bright, alert and responsive with rough furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - enlarged spleen, area=17x7; testes - small testis, area=6.5x4,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of liver; rough surface with rounded edges, multiple nodules; diameters of nodules 3mm to 5mm

17 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - enlarged spleen, area=14x7,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough surface of liver; rough surface with multiple nodules,
Comments (in English): liver; Internal view of rough surface of liver with multiple nodules; rough surface with multiple nodules

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Skin: MP:0002169,
Comments (in English): The mouse had thining fur on thorax with area of 30x16mm. Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; eye - abnormal eye morphology, cloudy; spleen - enlarged spleen, area=21x6; sternum - abnormal sternum morphology, xiphoid process protrudes 3mm,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough and lobulated liver; rough and very lobulated,
Comments (in English): skin; Lateral view of thining hair on thorax

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lymph nodes - enlarged lymph nodes, area=L:4x2, R:4.5x2.5, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Right eye was closed and left eye was small. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): eye; Internal view of eyeballs; small left eyeball; 1.5mm in diameter

17 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Liver: MP:0000598,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - enlarged spleen, area=14x7,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough surface of liver; rough surface with multiple nodules,
Comments (in English): liver; Internal view of rough surface of liver with multiple nodules; rough surface with multiple nodules

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; spleen - normal, black region (4x4mm) on cranial-dorsal end,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Mfsd1^em1(IMPC)Tcp heterozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; eye - abnormal eye morphology, right eye sunken further into skull (could not bleed from it); spleen - enlarged spleen, area=20x7,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of liver; rough and lobulated

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Comments (in English): The mouse had thining fur on thorax with area of 30x16mm. Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; eye - abnormal eye morphology, cloudy; spleen - enlarged spleen, area=21x6; sternum - abnormal sternum morphology, xiphoid process protrudes 3mm,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough and lobulated liver; rough and very lobulated,
Comments (in English): skin; Lateral view of thining hair on thorax

16 weeks old

Mfsd1^em1(IMPC)Tcp homozygote

Liver: MP:0000598,
Comments (in English): The mouse had thining fur on thorax with area of 30x16mm. Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; eye - abnormal eye morphology, cloudy; spleen - enlarged spleen, area=21x6; sternum - abnormal sternum morphology, xiphoid process protrudes 3mm,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): liver; Internal view of rough and lobulated liver; rough and very lobulated,
Comments (in English): skin; Lateral view of thining hair on thorax