Histopathology data for Sirt4

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM M #1 Adrenal gland [MA:0000116] Not applicable 0
HOM M #3 Esophagus [MA:0000352] Not applicable 0
HOM F #4 Large intestine [MA:0000333] Not applicable 0
HOM M #3 Kidney [MA:0000368] Not applicable 0
HOM M #3 Lung [MA:0000415] Not applicable 0
HOM M #1 Small intestine [MA:0000337] Not applicable 0
HOM M #1 Mammary gland [MA:0000145] Not applicable
HOM M #3 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #3 Femur [MA:0001359] Not applicable 0
HOM F #2 Large intestine [MA:0000333] Not applicable 0
HOM F #2 Lymph node [MA:0000139] Not applicable 0
HOM M #1 Spleen [MA:0000141] Not applicable 0
HOM M #3 Trigeminal V nerve [MA:0001100] Not applicable
HOM M #1 Sternum [MA:0001331] Not applicable 0
HOM F #4 Lymph node [MA:0000139] Not applicable
HOM F #4 Brain [MA:0000168] Not applicable 0
HOM M #3 Prostate Not applicable 0
HOM M #1 Eye with optic nerve Not applicable 0
HOM F #4 Trachea [MA:0000441] Not applicable 0
HOM M #1 Trigeminal V nerve [MA:0001100] Not applicable
HOM M #1 Knee joint [MA:0000471] Not applicable 0
HOM F #2 Sciatic nerve [MA:0001172] Not applicable 0
HOM F #4 Pancreas [MA:0000120] Not applicable 0
HOM F #4 Femur [MA:0001359] Not applicable 0
HOM F #2 Urinary bladder [MA:0000380] Not applicable 0
HOM F #2 Ear [MA:0000236] Not applicable
HOM F #2 Ovary [MA:0000384] Not applicable 0
HOM F #2 Bone marrow [MA:0000134] Not applicable 0
HOM F #2 Gall bladder [MA:0000356] Not applicable 0
HOM F #4 Stomach [MA:0000353] Not applicable 0
HOM F #4 Lung [MA:0000415] Not applicable 0
HOM M #1 Bone [MA:0001459]
HOM F #2 Epididymis [MA:0000397] Not applicable 0
HOM M #3 Bone marrow [MA:0000134] Not applicable 0
HOM M #3 Spinal cord [MA:0000216] Not applicable 0
HOM M #3 Ear [MA:0000236] Not applicable
HOM M #1 Salivary gland [MA:0000346] Not applicable 0
HOM F #4 Tibia [MA:0001361] Not significant
HOM F #2 Kidney [MA:0000368] Not applicable 0
HOM M #3 Lymph node [MA:0000139] Not applicable 0
HOM M #1 Brown adipose tissue [MA:0000057] Not applicable
HOM F #2 Spinal cord [MA:0000216] Not applicable 0
HOM F #4 Heart [MA:0000072] Not applicable 0
HOM M #1 Nasal cavity [MA:0000284] Not applicable 0
HOM F #2 Liver [MA:0000358] Not applicable 0
HOM M #3 Small intestine [MA:0000337] Not applicable 0
HOM M #1 Lung [MA:0000415] Not applicable 0
HOM F #4 Kidney [MA:0000368] Not applicable 0
HOM M #1 Tongue [MA:0000347] Not applicable 0
HOM M #1 Liver [MA:0000358] Not applicable 0
HOM M #1 Esophagus [MA:0000352] Not applicable 0
HOM M #3 Large intestine [MA:0000333] Not applicable 0
HOM F #2 Thymus [MA:0000142] Not applicable 0
HOM F #4 Trigeminal V nerve [MA:0001100] Not applicable
HOM M #3 Pancreas [MA:0000120] Not applicable 0
HOM M #1 Femur [MA:0001359] Not applicable 0
HOM F #2 Thyroid Not applicable 0
HOM M #3 Spleen [MA:0000141] Not applicable 0
HOM F #2 Tooth [MA:0000348] Not applicable 0
HOM M #1 Tooth [MA:0000348] Not applicable 0
HOM F #4 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #3 Sciatic nerve [MA:0001172] Not applicable 0
HOM M #1 Skeletal muscle [MA:0003148] Not applicable 0
HOM M #1 Thyroid Not applicable 0
HOM F #4 Epididymis [MA:0000397] Not applicable 0
HOM F #4 Sciatic nerve [MA:0001172] Not applicable 0
HOM M #1 Skin [MA:0000151] Not applicable 0
HOM M #3 Tibia [MA:0001361] Not significant
HOM M #3 Knee joint [MA:0000471] Not applicable 0
HOM F #2 Pancreas [MA:0000120] Not applicable 0
HOM F #2 Femur [MA:0001359] Not applicable 0
HOM F #4 Thymus [MA:0000142] Not applicable 0
HOM F #2 Tongue [MA:0000347] Not applicable 0
HOM F #2 Lung [MA:0000415] Not applicable 0
HOM M #1 Testes Not applicable 0
HOM M #1 Ovary [MA:0000384] Not applicable 0
HOM M #1 Ear [MA:0000236] Not applicable
HOM M #1 Bone marrow [MA:0000134] Not applicable 0
HOM M #1 Spinal cord [MA:0000216] Not applicable 0
HOM F #2 Stomach [MA:0000353] Not applicable 0
HOM F #4 Uterus [MA:0000389] Not applicable 0
HOM F #2 Knee joint [MA:0000471] Not applicable 0
HOM M #3 Stomach [MA:0000353] Not applicable 0
HOM F #4 Prostate Not applicable 0
HOM M #1 Urinary bladder [MA:0000380] Not applicable 0
HOM F #2 Tibia [MA:0001361] Not significant
HOM M #3 Adrenal gland [MA:0000116] Not applicable 0
HOM F #4 Spleen [MA:0000141] Not applicable 0
HOM F #4 Salivary gland [MA:0000346] Not applicable 0
HOM F #2 Spleen [MA:0000141] Not applicable 0
HOM M #1 Lymph node [MA:0000139] Not applicable 0
HOM M #3 Brown adipose tissue [MA:0000057] Not applicable
HOM M #3 Nasal cavity [MA:0000284] Not applicable 0
HOM F #2 Adrenal gland [MA:0000116] Not applicable 0
HOM M #1 Gall bladder [MA:0000356] Not applicable
HOM M #3 Heart [MA:0000072] Not applicable 0
HOM M #3 Liver [MA:0000358] Not applicable 0
HOM F #4 Skin [MA:0000151] Not applicable 0
HOM M #1 Large intestine [MA:0000333] Not applicable 0
HOM F #4 Small intestine [MA:0000337] Not applicable 0
HOM M #3 Tongue [MA:0000347] Not applicable 0
HOM M #3 Thymus [MA:0000142] Not applicable 0
HOM F #2 Small intestine [MA:0000337] Not applicable 0
HOM F #4 Sternum [MA:0001331] Not applicable 0
HOM F #2 Sternum [MA:0001331] Not applicable 0
HOM M #1 Pancreas [MA:0000120] Not applicable 0
HOM M #1 Sciatic nerve [MA:0001172] Not applicable 0
HOM F #2 Skin [MA:0000151] Not applicable 0
HOM M #3 Tooth [MA:0000348] Not applicable 0
HOM F #4 Skeletal muscle [MA:0003148] tissue specific degenerative process [MPATH:25] 3 1 Myopathy; muscles of sternum
HOM F #2 Skeletal muscle [MA:0003148] Not applicable 0
HOM F #2 Prostate Not applicable 0
HOM F #4 Bone [MA:0001459]
HOM M #3 Uterus [MA:0000389] Not applicable 0
HOM M #1 Brain [MA:0000168] Not applicable 0
HOM M #3 Skeletal muscle [MA:0003148] tissue specific degenerative process [MPATH:25] 3 1 Myopathy; muscles of sternum
HOM F #4 Mammary gland [MA:0000145] Not applicable
HOM F #4 Tongue [MA:0000347] Not applicable 0
HOM M #3 Skin [MA:0000151] Not applicable 0
HOM M #3 Thyroid Not applicable 0
HOM F #4 Knee joint [MA:0000471] Not applicable 0
HOM M #1 Trachea [MA:0000441] Not applicable 0
HOM F #2 Testes Not applicable 0
HOM F #4 Eye with optic nerve Not applicable 0
HOM F #4 Adrenal gland [MA:0000116] Not applicable 0
HOM M #1 Tibia [MA:0001361] Not significant
HOM M #3 Urinary bladder [MA:0000380] Not applicable 0
HOM F #2 Uterus [MA:0000389] Not applicable 0
HOM M #3 Epididymis [MA:0000397] Not applicable 0
HOM M #1 Stomach [MA:0000353] Not applicable 0
HOM F #2 Brown adipose tissue [MA:0000057] Not applicable
HOM F #4 Nasal cavity [MA:0000284] Not applicable 0
HOM F #4 Liver [MA:0000358] Not applicable 0
HOM F #2 Esophagus [MA:0000352] Not applicable 0
HOM F #4 Spinal cord [MA:0000216] Not applicable 0
HOM F #2 Heart [MA:0000072] Not applicable 0
HOM F #4 Esophagus [MA:0000352] Not applicable 0
HOM M #1 Kidney [MA:0000368] Not applicable 0
HOM M #1 Heart [MA:0000072] Not applicable 0
HOM M #3 Testes Not applicable 0
HOM M #3 Ovary [MA:0000384] Not applicable 0
HOM F #2 Nasal cavity [MA:0000284] Not applicable 0
HOM M #3 Gall bladder [MA:0000356] Not applicable
HOM M #3 Mammary gland [MA:0000145] Not applicable
HOM F #4 Thyroid Not applicable 0
HOM F #4 Tooth [MA:0000348] Not applicable 0
HOM M #1 Thymus [MA:0000142] Not applicable 0
HOM M #1 Seminal vesicle [MA:0000410] Not applicable 0
HOM F #2 Seminal vesicle [MA:0000410] Not applicable 0
HOM M #3 Sternum [MA:0001331] Not applicable 0
HOM M #1 Uterus [MA:0000389] Not applicable 0
HOM F #2 Brain [MA:0000168] Not applicable 0
HOM M #3 Brain [MA:0000168] Not applicable 0
HOM M #3 Bone [MA:0001459]
HOM F #2 Trigeminal V nerve [MA:0001100] Not applicable
HOM F #2 Mammary gland [MA:0000145] Not applicable
HOM F #4 Ear [MA:0000236] Not applicable
HOM M #3 Eye with optic nerve Not applicable 0
HOM M #3 Trachea [MA:0000441] Not applicable 0
HOM F #4 Gall bladder [MA:0000356] Not applicable
HOM M #3 Salivary gland [MA:0000346] Not applicable 0
HOM F #4 Urinary bladder [MA:0000380] Not applicable 0
HOM F #4 Testes Not applicable 0
HOM F #4 Bone marrow [MA:0000134] Not applicable 0
HOM F #2 Trachea [MA:0000441] Not applicable 0
HOM F #2 Salivary gland [MA:0000346] Not applicable 0
HOM F #2 Eye with optic nerve Not applicable 0
HOM M #1 Prostate Not applicable 0
HOM F #2 Bone [MA:0001459]
HOM F #4 Ovary [MA:0000384] Not applicable 0
HOM M #1 Epididymis [MA:0000397] Not applicable 0
HOM F #4 Brown adipose tissue [MA:0000057] Not applicable

Associated histopathology images

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