Histopathology data for Pyroxd1

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET F #1 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET M #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #3 Thyroid normal [MPATH:458] 0 0
HET F #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #4 Mammary gland [MA:0000145] Not applicable
HET M #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #2 Testes normal [MPATH:458] 0 0
HET M #2 Thyroid normal [MPATH:458] 0 0
HET F #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #3 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #4 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET M #4 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET F #1 Testes Not applicable
HET M #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #2 Eye with optic nerve developmental and structural abnormality [MPATH:55] 1 0 chronic localized Retinal dysplasia.
HET M #4 Prostate normal [MPATH:458] 0 0
HET F #3 Testes Not applicable
HET M #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #3 Epididymis [MA:0000397] Not applicable
HET F #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET F #3 Eye with optic nerve normal [MPATH:458] 0 0
HET F #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #3 Prostate Not applicable
HET M #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #2 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #1 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET F #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #1 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET F #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #4 Testes normal [MPATH:458] 0 0
HET F #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #1 Thyroid normal [MPATH:458] 0 0
HET M #4 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #2 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET M #4 Thyroid normal [MPATH:458] 0 0
HET F #3 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET M #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #2 Prostate normal [MPATH:458] 0 0
HET F #3 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET M #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #4 Eye with optic nerve normal [MPATH:458] 0 0
HET M #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HET M #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #1 Prostate Not applicable
HET M #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #2 Mammary gland [MA:0000145] Not applicable
HET F #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HET F #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #3 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #1 Seminal vesicle [MA:0000410] Not applicable
HET F #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #3 Liver [MA:0000358] normal [MPATH:458] 0 0
HET F #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #3 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET M #4 Ovary [MA:0000384] Not applicable
HET M #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #4 Liver [MA:0000358] normal [MPATH:458] 0 0
HET F #3 Seminal vesicle [MA:0000410] Not applicable
HET F #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET M #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #4 Uterus [MA:0000389] Not applicable
HET M #4 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #1
HET F #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #2 Ovary [MA:0000384] Not applicable
HET F #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET F #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #1 Eye with optic nerve process of degenerative change [MPATH:14] 4 0 unilateral chronic Retinal dysplasia, cataract, and posterior and anterior synechia.
HET M #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #1 Epididymis [MA:0000397] Not applicable
HET F #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #1 Sciatic nerve [MA:0001172] normal [MPATH:458] 0 0
HET M #2 Uterus [MA:0000389] Not applicable

Associated histopathology images

Pyroxd1
heterozygote
Eye with optic nerve MA:0000261
MA:0000261 eye
Pyroxd1tm1b(KOMP)Wtsi
experimental

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter