Histopathology data for Myo7a

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM M #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM F #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM M #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM M #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM F #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM M #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM M #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #2 Testes normal [MPATH:458] 0 0
HOM M #2 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM M #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #1 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM M #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #4 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM F #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM F #4 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM F #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM F #4 Ovary [MA:0000384] normal [MPATH:458] 0 0
HOM M #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM F #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM M #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #1 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM F #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM F #1 Eye with optic nerve developmental dysplasia [MPATH:64] 1 0 multi-localised Retinal dysplasia
HOM M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM M #3 Thyroid normal [MPATH:458] 0 0
HOM F #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM F #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM M #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM M #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HOM M #3 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM F #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM M #2 Sternum [MA:0001331] process of degenerative change [MPATH:14] 3 0 focally extensive chronic-active Sternomanubrium dislocation
HOM F #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM F #1 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM F #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM M #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #2 Prostate normal [MPATH:458] 0 0
HOM F #1 Uterus [MA:0000389] normal [MPATH:458] 0 0
HOM M #2 Eye with optic nerve normal [MPATH:458] 0 0
HOM M #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM F #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM F #4 Eye with optic nerve developmental and structural abnormality [MPATH:55] inflammation [MPATH:212]
HOM M #3 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM F #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #3 Eye with optic nerve normal [MPATH:458] 0 0
HOM F #1 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM M #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM M #3 Prostate normal [MPATH:458] 0 0
HOM F #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM M #2 Brain [MA:0000168] process of degenerative change [MPATH:14] 2 0 distributed Dilation of the brain ventricles
HOM F #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM M #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HOM F #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #3 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM F #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM M #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HOM F #1 Thyroid normal [MPATH:458] 0 0
HOM F #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #4 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM M #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HOM M #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HOM F #4 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM M #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HOM F #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM M #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM F #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HOM F #4 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HOM F #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM F #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HOM M #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM F #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HOM M #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM M #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HOM F #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HOM M #2 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HOM F #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM M #3 Testes normal [MPATH:458] 0 0
HOM M #2 Thyroid normal [MPATH:458] 0 0
HOM F #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HOM F #4 Eye with optic nerve Not applicable 0 Microphtalmia
HOM M #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HOM F #4 Eye with optic nerve 1 0 Mild keratitis
HOM F #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HOM M #3 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HOM M #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HOM F #1 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HOM F #4 Brain [MA:0000168] process of degenerative change [MPATH:14] 2 0 distributed Dilation of the brain ventricles
HOM M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HOM M #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HOM M #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HOM M #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HOM F #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HOM M #2 Liver [MA:0000358] normal [MPATH:458] 0 0
HOM F #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HOM M #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HOM M #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HOM F #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HOM F #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HOM M #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HOM F #4 Thyroid normal [MPATH:458] 0 0
HOM F #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0

Associated histopathology images

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